An investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodine

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dc.authorid0000-0002-2966-9627en_US
dc.contributor.authorBüyüksoylu, Semih
dc.contributor.authorÖzgür, Mustafa Erkan
dc.contributor.authorGül, Cemile Ceren
dc.contributor.authorTaşlıdere, Aslı Çetin
dc.contributor.authorAydemir, Songül
dc.contributor.authorErdoǧan, Selim
dc.date.accessioned2021-06-14T19:58:02Z
dc.date.available2021-06-14T19:58:02Z
dc.date.issued2020en_US
dc.departmentMTÖ Üniversitesi, Doğanşehir Vahap Küçük Meslek Yüksekokulu, Su Ürünleri Bölümüen_US
dc.description.abstractThe purpose of this research is to determine ecotoxicological effects of dodine (n-dodecylguanidini acetate) on aquatic environments. Though dodine is widely used as a fungicide in agriculture, but there is no much data about its ecotoxicology. In this regard, we investigated bioaccumulation levels and histological alterations on the tissues of muscle, liver and gills in Rainbow Trout (Oncorhynchus mykiss) against different doses (0.01, 0.1, 0.5 and 1?mg/L) of Dodine exposure. The tissues of fish were extracted according to QUECHERS method and analyzed by mass spectrometer (LC-MS-MS). Neither of the applied dodine doses resulted in killing 50% of the total individuals in the experimental groups. However, 48?hours after doses, behaviors such as instability, anomaly in swimming or sudden jumping movements were observed. Histological results of the study showed deteriorations of the radiological pattern of hepatocytes, sinusoidal dilatations, hemorrhages, edemas, mononuclear cell infiltrations, vascular congestions, hyperplasia and hypertrophy in liver, gill and muscle tissues. Accumulation of dodine in tissues correlated with increase of dose. The maximum level of active substance accumulation in tissues were measured 96?hours after application of 1?mg/L dodine dose -in order- in gills, muscles and liver. The accumulations were statistically significant (p?<?0.05) when compared with control group.en_US
dc.identifier.citationBüyüksoylu, S., Özgür, M. E., Gül, C. C., Taşlıdere, A., Aydemir, S., & Erdoğan, S. (2020). An investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodine. Drug and Chemical Toxicology, 1-11.en_US
dc.identifier.doi10.1080/01480545.2020.1730884
dc.identifier.endpage11en_US
dc.identifier.issn0148-0545en_US
dc.identifier.issn1525-6014en_US
dc.identifier.pmid32102573
dc.identifier.scopus2-s2.0-85080052259en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1730884
dc.identifier.urihttps://hdl.handle.net/20.500.12899/253
dc.identifier.wosWOS:000517037600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzgür, Mustafa Erkan
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDodineen_US
dc.subjectFungicideen_US
dc.subjectOncorhynchus mykissen_US
dc.subjectLC-MS-MSen_US
dc.subjectQUECHERSen_US
dc.titleAn investigation of histopathological changes and bioaccumulation in tissues of rainbow trout (Oncorhynchus mykiss) after exposure to dodineen_US
dc.typeArticleen_US

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