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Öğe The effects of lornoksikam and intravenous iboprofen in lower extremity ischemia reperfusion injury(Wiley-Blackwell, 2016) Kucuk, A.; Aydin, M. E.; Koc, D. S.; Sivgin, V.; Arslan, M.; Comu, F. M.; Kosem, B.[Abstract Not Available]Öğe The impact of IL-33 in absence epilepsy(Wiley-Blackwell, 2014) Akkilik, Z. Seckin; Gurol, G.; Sari, S.; Arabaci, S.; Yukselten, Y.; Guneri, D.; Ekici, F.[Abstract Not Available]Öğe Role of ADAMTS2 and ADAMTS5 Genes in Radioiodine Induced Damage to the Salivary Glands of Rats: Genetic, Immunohistochemical and Histopathological Evaluations(Springer, 2016) Sadic, M.; Demirel, K.; Halacli, S. O.; Karakok, E.; Koca, G.; Ekinci, O.; Demircan, K.[Abstract Not Available]Öğe A disintegrin-like metalloproteinase with thrombospondin motif 8 expression analysis in OUMS-27 chondrosarcoma cells before and after insulin administration(Natl Inst Science Communication-Niscair, 2016) Erden, Gonul; Akyol, Sumeyya; Comertoglu, Ismail; Altuntas, Aynur; Cakmak, Ozlem; Ugurcu, Veli; Yukselten, YunusA disintegrin-like and metalloproteinase with thrombospondin motif 8 (ADAMTS8) is a secreted protease with anti-angiogenic properties. It inhibits vascular endothelial growth factor (VEGF) induced angiogenesis and suppresses fibroblast growth factor 2 (FGF-2) induced vascularization. Angiogenesis and extracellular matrix degradation are the key events in tumor progression, and ADAMTS8 is also known to be a member of the aggrecanases family. In the present study, we investigated the expression levels of ADAMTS8 in chondrosarcoma cells to elucidate the effect of insulin on the tumor cells in terms of ADAMTS production. The OUMS-27 cells were cultured and separately exposed to 10 mu mol/mL insulin up to 11 days in Dulbecco's modified Eagle's medium. After specific time limits (days 1, 3, 7, and 11), the culture was terminated and RNA was isolated using TRIzol reagent and converted to cDNA. The expression levels of ADAMTS8 were evaluated by qRT-PCR. The ADAMTS8 expression in OUMS-27 cells exhibited about 4-fold decrease following insulin treatment on day 11. Statistically significant differences were noted between the control and day 1 (P = 0.008), day 7 (P = 0.047) and day 11 (P = 0.008) groups. The effect of insulin on chondrosarcoma cells in terms of ADAMTS8 expression has not been reported earlier. The decrease in ADAMTS8 expression could be considered as a novel finding that has the potential to explain some pathophysiological mechanisms of tumor cells. Furthermore, the finding could also shed some light on the relationships between matrix degradation and insulin treatment in vitro.Öğe A Study on the Depiction of Disability in Illustrated Story Books(Expert Projects Publishing, 2015) Gonen, Mubeccel; Dursun, Aylin; Bilir, Zeynep Topcu; Tarman, Ilknur; Nur, ImrayThe aim of the present study is to examine illustrated storybooks depicting people with disabilities, in terms of their content and the type of disabilities they feature and to analyze the disabilities in the books that could be reached. The study was carried out in the survey design. Within the scope of the study, three largest bookstores in Ankara, Turkey and the websites offering online book shopping were surveyed and 234 illustrated story books were reviewed. Among these books, 30 illustrated storybooks, which depict people with disabilities, were included in the study. In order to examine the characters with illnesses and disabilities in the illustrated books, the study employed the Checklist to be used for Analysis of Children's Literature that includes People with Disabilities used in Inclusive Education, which was developed by Blaska. Although some examples found by the study results were rather negative, there are still some illustrated storybooks that depict disability correctly and help children respect people with disabilities by providing them with appropriate understanding of people with disabilities and disabilities themselves. However, despite the increase, it was seen that the number of books in this field is not sufficient.Öğe LINEAR DISCRIMINANT ANALYSIS OF ELECTRON BEAM EFFECTS ON THE RELATIVISTIC LASER-PRODUCED K-SHELL AL PLASMAS(Ieee, 2015) Yilmaz, M. Fatih; Danisman, Yusuf; Safronova, A. S.; Kantsyrev, V. L.; Wiewior, P.; Stafford, A.; Shrestha, I. K.[Abstract Not Available]Öğe The importance of coronary angiography for ischemic sign confirmation detected by myocardial perfusion scintigraphy Reply(Tubitak Scientific & Technological Research Council Turkey, 2016) Erkan, Melih Engin; Asik, Muhammet; Ucgun, Taner; Yildiz, Nilgun; Yilmaz, Ayse; Aslantas, Yusuf; Bulur, Serkan[Abstract Not Available]Öğe The Effect of Daily Activities on the Activity of Stress Axes in Preschool Children(Wiley, 2023) Cevizci, Hediye; Barutcu, Ozlem; Cevizci, Nuri; Ozgocer, Tuba; Ucar, Cihat; Yildiz, Sedat; Gul, Mustafa[Abstract Not Available]Öğe Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma(Ijo Press, 2016) Ergan, Esra; Ozturk, Farak; Beyazyildiz, Emrullah; Elgin, Ufuk; Sen, Emine; Cankaya, Ali Bulent; Celik, TugrulAIM: To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma. METHODS: The prospective study was composed of a study group (n=31) and a control group (a=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non -glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels. RESULTS: Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG. CONCLUSION: High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.Öğe ARRAY-CGH AND CLINICAL FINDINGS IN A PATIENT WITH A SMALL SUPERNUMERARY r(8) MOSAICISM(Medecine Et Hygiene, 2014) Eyupoglu, F. Celep; Sunnetci, D.; Cine, N.; Savli, H.; Okten, A.; Acikgoz, E. Gul; Sonmez, F. M.Array-CGH and clinical findings in a patient with a small supernumerary r(8) mosaicism: Small supernumerary ring chromosomes (sSRC) represent a subset of small supernumerary marker chromosomes (sSMC) where r(8) is relatively common. The phenotype sSRC(8) ranges from almost normal to variable degrees of abnormalities in mosaic or non-mosaic conditions. We present a new patient of de novo mosaic supernumerary ring chromosome 8 which has trisomy of a region of chromosome 8p11.21-q21.13. Mosaicism for a ring chromosome was showed by routine karyotyping that revealed a karyotype of mos47,XY,+r(?) [47]/46,XY [36] and we performed array comparative genomic hybridization (array-CGH) in order to precisely define the extension about chromosomal origin of the duplicated region in a patient. Array-CGH analysis confirmed that the sSRC derived a 43.921 Mb genomic gain of chromosome 8 (p11.21-q21.13). Common clinical features of the patient included multiple congenital anomalies, developmental delay, thoracolumbar scoliosis, mild pulmonary stenosis, laryngomalacia, hypospadias and atypical facial appearance. With this study a patient involving mosaic trisomy 8p11.21-q21.13 along with clinical properties, is described and compared to previously reported cases involving partial trisomy 8q.Öğe Investigation of four colorectal cancer related single nucleotide polymorphisms in Turkish sporadic colorectal cancer cases(Wiley-Blackwell, 2016) Cumaogullari, O.; Tekin, N.; Rajabli, F.; Dag, O. Ilk; Kuzu, M. A.; Ozdag, H.[Abstract Not Available]Öğe PCA MODELING OF THE L-SHELL COPPER X-PINCH PLASMA PRODUCED BY THE COMPACT GENERATOR OF ECOLE POLYTECHNIQUE(Ieee, 2015) Larour, Jean; Aranchuk, Leonid E.; Yilmaz, M. Fatih; Eleyan, Alaa; Danisman, Yusuf[Abstract Not Available]Öğe Laparoscopic Nissen fundoplication with mesh-hiatoplasty: Single center experience and early-term results(Canadian Soc Clinical Investigation, 2016) Kafadar, Mehmet Tolga; Yalaza, Metin; Turkan, Ahmet; Surgit, Onder; Degirmencioglu, Gurkan; Nadir, IsilayPurpose: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. Methods: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation. All operations were performed under general anesthesia using five ports. In addition to Nissen fundoplication, all patients also underwent polypropylene mesh placement. Results: Preoperatively, all patients reported a burning sensation in the chest and regurgitation of the stomach contents up into the mouth. The mean time from symptom onset to operation was 28 (6-84) months. All patients were diagnosed with esophagitis in the preoperative endoscopic examination. The mean operative time was 80 (40-125) minutes, the median duration of hospital stay was 1.2 (1-4) days and the median follow- up time was 12 (2-30) months. Functional outcome was excellent in 65% of patients, good in 24.5%, moderately good in 7% and poor in 3.5%. Conclusion: Fundoplication with mesh hiatoplasty is a surgical procedure performed for the traetment of gastroesophageal reflux disease and hiatal hernia. Surgery can be safely carried out with low morbidity and mortality rates and constitutes an alternative to long-term drug therapy. We believe that this operation is beneficial since it reduces the rate of recurrences to a significant degree.Öğe The impact of thrombospondin-1 in pathophysiology of absence epilepsy(Wiley-Blackwell, 2014) Gurol, G.; Akkilik, Z. Seckin; Arabaci, S.; Sari, S.; Yukselten, Y.; Yeni, A. E.; Guneri, D.[Abstract Not Available]Öğe Evaluation of the expression of ADAMTS-3,-4 and-15 genes in parotid and submandibular salivary glands after RAI therapy(Springer, 2015) Sadic, M.; Atilgan, H. I.; Halacli, S. O.; Demircan, K.; Korkmaz, M.[Abstract Not Available]Öğe Comparison of Pulmonary Hydatid Cysts between Men and Women(Kuwait Medical Assoc, 2016) Metin, Bayram; Aribas, Olgun Kadir; Dumanli, Ahmet; Aribas, Emel TurkObjective(s): To discuss the features of pulmonary hydatid cysts in male and female patients in terms of clinical, radiological, and surgical approaches Design: Retrospective study Setting: Thoracic surgery clinics of two universities in Turkey Subjects: Comparison of pulmonary hydatid cysts between men and women Intervention(s): Over the last 10 years, surgery was performed on 84 patients with pulmonary hydatid cysts (62 female and 22 male). Main outcome measure(s): The patients in both groups were analyzed according to clinical, radiological, surgical, and postoperative characteristics. Results: In this study, the number of female patients who underwent surgery due to pulmonary hydatid cysts was significantly higher than males. In our study, cyst diameter was found to be greater in men than women (respectively, 7.018 cm and 4.560 cm; p = 0.001). When women and men were compared with respect to the rate of total complications, they were found to be higher in men than in women (p = 0.043). Length of hospital stay after surgery was also longer in men (15.29 d) than in women (6.90 d; p = 0.0001). Conclusion(s): In our study, cyst diameter was found to be greater in men than women. Perhaps it may be related to lung and thorax volume being 20-25% smaller in women than in men. In order to reveal the differences between women and men for pulmonary hydatid cysts, there is a need for studies covering both large numbers of cases and large endemic areas.Öğe Does the wedge wing in the neck screw prevent cut-out failure in OTA/AO 31-A2 trochanteric fractures in elderly patients?(Acta Medica Belgica, 2014) Gunay, Cuneyd; Atalar, Hakan; Altay, Murat; Yavuz, Osman Yuksel; Yildirim, Ahmet Ozgur; Oken, Ozdamar FuadThe purpose of this retrospective study was to evaluate the effects of Dyna Locking Trochanteric (DLT) nail (U & I Corporation 529-1, Yonghyun-dong, Uijungbu Kyunggi-Do, Korea 480-050) in 31-A1 and 31-A2 intertrochanteric femur fractures. Eighty-seven patients (63 female and 24 male, mean age 77 years) were treated. The mean duration of follow-up was 16.6 +/- 3.1 months (range, 12-24 months). There were 36 cases of 31-A1 and 51 cases of 31-A2 fractures. The duration of surgery, fluoroscopy screening time, the blood loss, the hospital stay, the tip-apex distance were significantly less in the 31-A1 fracture group compared with the 31-A2 fracture group (p < 0.001). Cut-out was observed in 13 patients (14.9%) above 80 years old with 31-A2 fractures. Especially in elderly patients with unstable 31-A2 fractures, the wedge wing on the neck screw does not work properly. Therefore further biomechanical investigations and also prospective clinical studies with larger series are needed to improve the device.Öğe Effect of combined anti-inflammatory and antioxidant therapy on ischemia-reperfusion injury in rat ovary: an experimental study(E-Century Publishing Corp, 2016) Kaya, Murat; Ozkan, Aybars; Eroz, Recep; Soyer, Tutku; Kabaklioglu, Murat; Oktay, Murat; Demirin, HilmiAn experiemental study was performed to evaluate the effect of combined anti-inflammatory and antioxidant theraphy on ischemia-reperfusion injury in rat ovary. Also the results of combined theraphy is aimed to compared with monotherapy. Fifty-four female Wistar rats were randomly divided into 9 equal groups (n=6). In Sham group right ovaries of the rats were sampled without generating ischemia and reperfusion injury via median laparatomy. Ischemia/Reperfusion (I/R) was performed by clamping the vascular supply of right ovary for 3 hours (I/R 1 group) and 6 hours (I/R 2 group), respectively. After one hour reperfusion, rats recieved 20 mg/kg Methylprednisolone (Pred 1; 3 hours ischemia and Pred 2; 6 hours ischemia) and 50 mg/kg Vitamin C (Vit C 1; 3 hours ischemia and Vit C 2; 6 hours ischemia). The combined therapy groups (Pred+Vit C 1 and Pred+Vit C 2) were adminstered same doses of both Methylprednisolone and Vitamin C. Rats were sacrifed after 24 hours of reperfusion and ovarian tissues were sampled for oxidative markers [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] biochemically. Histopathological findings of inflammation (follicular cell degeneration, vascular congestion, hemorrhage and infiltration by inflammatory cells) were also evaluated with an injury score grading normal findings to severe injury (Grade 0 to 3). The results were compared among groups. Mean levels of antioxidant enzymes and histopathologic grades showed significant difference among groups (P<0.05). MDA and CAT levels were lower in Pred+Vit C 1 than Pred 1, Vit C 1 and I/R 1 (P<0.05). SOD and CAT levels were lower in Pred+Vit C 2 than Pred 2 and I/R 2. Total injury scores were lower in Pred+Vit C 1 and Pred+Vit C 2 than I/R 1 and I/R 2 (P<0.05). The combined treatment of anti-oxidant and anti-inflammatory theraphy reduces the biochemical and histopathologic findings of I/R injury in rat ovary. These results are significantly comparable with the effect of monotheraphy.Öğe PHACOMATOSIS PIGMENTOVASCULARIS TYPE IIB ASSOCIATED WITH STURGE-WEBER SYNDROME: A CASE REPORT AND REVIEW OF THE LITERATURE(Medecine Et Hygiene, 2013) Sonmez, F. M.; Aksoy, A.; Sari, A.; Erpolat, S.; Ozkaya, A. K.[Abstract Not Available]Öğe A Financial Cost Metric for Result Caching(Assoc Computing Machinery, 2013) Sazoglu, Fethi Burak; Cambazoglu, B. Barla; Ozcan, Rifat; Altingovde, Ismail Sengor; Ulusoy, OzgurWeb search engines cache results of frequent and/or recent queries. Result caching strategies can be evaluated using different metrics, hit rate being the most well-known. Recent works take the processing overhead of queries into account when evaluating the performance of result caching strategies and propose cost-aware caching strategies. In this paper, we propose a financial cost metric that goes one step beyond and takes also the hourly electricity prices into account when computing the cost. We evaluate the most well-known static, dynamic, and hybrid result caching strategies under this new metric. Moreover, we propose a financial-cost-aware version of the well-known LRU strategy and show that it outperforms the original LRU strategy in terms of the financial cost metric.
