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Öğe Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma(Ijo Press, 2016) Ergan, Esra; Ozturk, Farak; Beyazyildiz, Emrullah; Elgin, Ufuk; Sen, Emine; Cankaya, Ali Bulent; Celik, TugrulAIM: To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma. METHODS: The prospective study was composed of a study group (n=31) and a control group (a=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non -glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels. RESULTS: Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG. CONCLUSION: High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.Öğe Laparoscopic Nissen fundoplication with mesh-hiatoplasty: Single center experience and early-term results(Canadian Soc Clinical Investigation, 2016) Kafadar, Mehmet Tolga; Yalaza, Metin; Turkan, Ahmet; Surgit, Onder; Degirmencioglu, Gurkan; Nadir, IsilayPurpose: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. Methods: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation. All operations were performed under general anesthesia using five ports. In addition to Nissen fundoplication, all patients also underwent polypropylene mesh placement. Results: Preoperatively, all patients reported a burning sensation in the chest and regurgitation of the stomach contents up into the mouth. The mean time from symptom onset to operation was 28 (6-84) months. All patients were diagnosed with esophagitis in the preoperative endoscopic examination. The mean operative time was 80 (40-125) minutes, the median duration of hospital stay was 1.2 (1-4) days and the median follow- up time was 12 (2-30) months. Functional outcome was excellent in 65% of patients, good in 24.5%, moderately good in 7% and poor in 3.5%. Conclusion: Fundoplication with mesh hiatoplasty is a surgical procedure performed for the traetment of gastroesophageal reflux disease and hiatal hernia. Surgery can be safely carried out with low morbidity and mortality rates and constitutes an alternative to long-term drug therapy. We believe that this operation is beneficial since it reduces the rate of recurrences to a significant degree.Öğe Comparison of Pulmonary Hydatid Cysts between Men and Women(Kuwait Medical Assoc, 2016) Metin, Bayram; Aribas, Olgun Kadir; Dumanli, Ahmet; Aribas, Emel TurkObjective(s): To discuss the features of pulmonary hydatid cysts in male and female patients in terms of clinical, radiological, and surgical approaches Design: Retrospective study Setting: Thoracic surgery clinics of two universities in Turkey Subjects: Comparison of pulmonary hydatid cysts between men and women Intervention(s): Over the last 10 years, surgery was performed on 84 patients with pulmonary hydatid cysts (62 female and 22 male). Main outcome measure(s): The patients in both groups were analyzed according to clinical, radiological, surgical, and postoperative characteristics. Results: In this study, the number of female patients who underwent surgery due to pulmonary hydatid cysts was significantly higher than males. In our study, cyst diameter was found to be greater in men than women (respectively, 7.018 cm and 4.560 cm; p = 0.001). When women and men were compared with respect to the rate of total complications, they were found to be higher in men than in women (p = 0.043). Length of hospital stay after surgery was also longer in men (15.29 d) than in women (6.90 d; p = 0.0001). Conclusion(s): In our study, cyst diameter was found to be greater in men than women. Perhaps it may be related to lung and thorax volume being 20-25% smaller in women than in men. In order to reveal the differences between women and men for pulmonary hydatid cysts, there is a need for studies covering both large numbers of cases and large endemic areas.Öğe Effect of combined anti-inflammatory and antioxidant therapy on ischemia-reperfusion injury in rat ovary: an experimental study(E-Century Publishing Corp, 2016) Kaya, Murat; Ozkan, Aybars; Eroz, Recep; Soyer, Tutku; Kabaklioglu, Murat; Oktay, Murat; Demirin, HilmiAn experiemental study was performed to evaluate the effect of combined anti-inflammatory and antioxidant theraphy on ischemia-reperfusion injury in rat ovary. Also the results of combined theraphy is aimed to compared with monotherapy. Fifty-four female Wistar rats were randomly divided into 9 equal groups (n=6). In Sham group right ovaries of the rats were sampled without generating ischemia and reperfusion injury via median laparatomy. Ischemia/Reperfusion (I/R) was performed by clamping the vascular supply of right ovary for 3 hours (I/R 1 group) and 6 hours (I/R 2 group), respectively. After one hour reperfusion, rats recieved 20 mg/kg Methylprednisolone (Pred 1; 3 hours ischemia and Pred 2; 6 hours ischemia) and 50 mg/kg Vitamin C (Vit C 1; 3 hours ischemia and Vit C 2; 6 hours ischemia). The combined therapy groups (Pred+Vit C 1 and Pred+Vit C 2) were adminstered same doses of both Methylprednisolone and Vitamin C. Rats were sacrifed after 24 hours of reperfusion and ovarian tissues were sampled for oxidative markers [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] biochemically. Histopathological findings of inflammation (follicular cell degeneration, vascular congestion, hemorrhage and infiltration by inflammatory cells) were also evaluated with an injury score grading normal findings to severe injury (Grade 0 to 3). The results were compared among groups. Mean levels of antioxidant enzymes and histopathologic grades showed significant difference among groups (P<0.05). MDA and CAT levels were lower in Pred+Vit C 1 than Pred 1, Vit C 1 and I/R 1 (P<0.05). SOD and CAT levels were lower in Pred+Vit C 2 than Pred 2 and I/R 2. Total injury scores were lower in Pred+Vit C 1 and Pred+Vit C 2 than I/R 1 and I/R 2 (P<0.05). The combined treatment of anti-oxidant and anti-inflammatory theraphy reduces the biochemical and histopathologic findings of I/R injury in rat ovary. These results are significantly comparable with the effect of monotheraphy.Öğe A Financial Cost Metric for Result Caching(Assoc Computing Machinery, 2013) Sazoglu, Fethi Burak; Cambazoglu, B. Barla; Ozcan, Rifat; Altingovde, Ismail Sengor; Ulusoy, OzgurWeb search engines cache results of frequent and/or recent queries. Result caching strategies can be evaluated using different metrics, hit rate being the most well-known. Recent works take the processing overhead of queries into account when evaluating the performance of result caching strategies and propose cost-aware caching strategies. In this paper, we propose a financial cost metric that goes one step beyond and takes also the hourly electricity prices into account when computing the cost. We evaluate the most well-known static, dynamic, and hybrid result caching strategies under this new metric. Moreover, we propose a financial-cost-aware version of the well-known LRU strategy and show that it outperforms the original LRU strategy in terms of the financial cost metric.Öğe Understanding thermal sensitivity at the molecular level and developing temperature-based systems using RNA Thermometers(Canadian Soc Clinical Investigation, 2016) Gul, Fatih; Orhan, Ibrahim Y.; Ceylan, Furkan S.; Akdeniz, Nadir B.; Karadag, H. AbdulkadirPurpose: Temperature sensitivity is found in all multicelleular organisms, as well as in most primitive life forms. The ubiquity of this temperature sensitivity is an indicator of its effects at the multicellular, cellular and molecular levels [1]. Previous studies have shown that temperature-based regulation is present in the transcriptional process [2]. RNA Thermometers, temperature-sensitive sequences, have been shown to act on heat-shock genes to regulate temperature-dependant systems in many organisms [3,4]. The goal of this study was to characterize the shifts in the functioning of these RNA Thermometers at various temperatures. In addition, using the principle of transcriptional thermoregulation, an automated temperature-responsive system stimulating inverse endothermic and exothermic enzymatic reactions for heat stabilization was proposed. Methods: The endothermic enzymatic reaction was designated as the breakdown of urea, reflecting the function of urease, and the exothermic reaction was designated as the breakdown of hydrogen peroxide, reflecting the function of catalase [5]. Results: The proposed system was built upon the translation of urease and the inhibition of catalase translation at higher temperatures, and the inverse at lower temperatures. As RNA Thermometers can be used only to drive transcription at higher temperatures, the installation of a lac-regulated 2-way system was suggested. This system would also provide a synthetic solution to thermoregulation and the current systems employed today. This system could be applied where the current thermoregulatory systems prove insufficient and could be further developed and optimized to replace them in the future.Öğe Optimal Jamming of Wireless Localization Systems(Ieee, 2015) Gezici, Sinan; Gholami, Mohammad Reza; Bayram, Suat; Jansson, MagnusIn this study, optimal jamming of wireless localization systems is investigated. Two optimal power allocation schemes are proposed for jammer nodes in the presence of total and peak power constraints. In the first scheme, power is allocated to jammer nodes in order to maximize the average Cramer-Rao lower hound (CRLB) of target nodes whereas in the second scheme the power allocation is performed for the aim of maximizing the minimum CRLB of target nodes. Both schemes are formulated as linear programs, and a closed-form expression is obtained for the first scheme. Also, the full total power utilization property is specified for the second scheme. Simulation results are presented to investigate perlbrmance of the proposed schemes.Öğe Intradiploic Epidermoid Cyst on Occipital Bone during Childhood: a case report and review of the literature(Journal Neurological Sciences, 2016) Guvenc, Yahya; Gokce, Emre Cemal; Gokce, Aysun; Guvenc, Fatma TugbaIntracranial epidermoid cyst is an uncommon tumor of head, and contains only 1% of all intracranial tumors. Epidermoid cysts are benign and slowly growing lesions. It is mostly seen at 3rd and 4th decade. In our study, bening epidermoid cyst at a rarely seen age, rarely seen localization extended from intradiploic area to epidural space, its clinic and surgical treatment have been presented. In our study, an 11 years old patient presented to clinic with complaint of swelling on scalp that grows slowly and painlessly which he recognized 5 months ago. There were bone defect at a focal area at occipital bone and mass appearances adjacent to the defect on radiological analyses. The patient was taken into operation, and the mass was removed totally together with its capsule. The patient post-operative course was uneventful, without any neurological deficit and was discharged after 1 day of hospitalisation. When mass is removed totally, prognosis has long and good course. Any patient applying to hospital with complaint of painless and slowly growing swelling on scalp should be investigated carefully.Öğe Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?(Canadian Soc Clinical Investigation, 2016) Selcoki, Yusuf; Aydin, H. Ibrahim; Celik, Tugrul H.; Isleyen, Ahmet; Erayman, Ali; Demircelik, M. Bora; Demirin, HilmiPurpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age-and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2 +/- 3.0 mm vs. 39.6 +/- 3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p = 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.Öğe Optimal Jammer Placement in Wireless Localization Networks(Ieee, 2015) Gezici, Sinan; Bayram, Suat; Gholami, Mohammad Reza; Jansson, MagnusThe optimal jammer placement problem is proposed for a wireless localization network, where the aim is to degrade the accuracy of locating target nodes as much as possible. In particular, the optimal location of a jammer node is obtained in order to maximize the minimum of the Cramer-Rao lower bounds for a number of target nodes under location related constraints for the jammer node. Theoretical results are derived to specify scenarios in which the jammer node should be located as close to a certain target node as possible, or the optimal location of the jammer node is determined by two or three of the target nodes. In addition, explicit expressions for the optimal location of the jammer node are derived in the presence of two target nodes. Numerical examples are presented to illustrate the theoretical results.Öğe Teething and affecting factors: experiences from Turkey(Edizioni Minerva Medica, 2016) Yilmaz, Ayse E.; Dogan, Guzide; Akelma, Ahmet Z.; Karabel, Musemma; Karabel, Duran; Akca, Halise; Erdur, Emire A.BACKGROUND: The aim of this study was to investigate the experiences of Turkish mothers in teething period and the factors affecting teething. METHODS: This study was performed by filling in questionnaire forms with a face-to-face interview technique with the mothers of 792 patients presenting to the outpatient clinics of pediatrics of Fatih (Turgut Ozal) University Faculty of Medicine between 1 April and 31 July 2012. RESULTS: This study was conducted in a total of 792 children (mean age: 24.2 +/- 7.9, range 12-42 months; 430 males). Of the study population, 6.1% had a family history of premature teething, 9.7% had a family history of delayed teething, 98% had been breastfed, 91.9% had used vitamin D, 67.6% had used iron supplements, and 3.9% had fluorine use. The first teething was at 7.8 +/- 2.5 months and the first teeth to appear was the anterior lower incisor (58.7%). The symptoms the patients had during teething were irritability (64.9%), fever (64.1%), increased mastication (61.6%), increased salivation (58.2%), and diarrhea (45.6%). The rate of admission to a physician with these complaints was 19.6%. The factors affecting the teething time were a family history of premature or delayed teething and birth with natal tooth, and male gender. CONCLUSIONS: In this study we found that nutritional or local factors were not effective on teething time. Teething period was characterized by nonspecific symptoms including irritability, subfebrile fever, increased mastication and salivation, and diarrhea. Linear regression analysis revealed that male gender and a family history of premature teething were the factors responsible from a shortening in teething time.Öğe Enhancements to Threshold Based Range Estimation for Ultra-Wideband Systems(Ieee, 2014) Soganci, Hama; Gezici, Sinan; Guldogan, Mehmet BurakUltra-wideband (UWB) signals have very high time resolution, which makes them a very good candidate for range estimation based wireless positioning. Although the accuracy is the major concern for range estimation, it is also important to have low-complexity algorithms that can be employed in real time. In this study, two low-complexity range estimation algorithms are proposed for UWB signals, which achieve improved performance compared to the state-of-the-art low-complexity ranging algorithms. The proposed algorithms are inspired from two well-known algorithms; 'serial backward search' (SBS) and 'jump back and search forward' (JBSF). Performances of the proposed algorithms are compared with those of the SBS and JBSF algorithms based on real measurements. In addition, theoretical bounds are calculated in order to quantify the statistical performance of the algorithms.Öğe Fear of Death and Sleep Quality in the Aftermath of an Earthquake(Slack Inc, 2025) Aktura, Seher Cevik; Celik, Hanife; Saritas, Seyhan Citlik; Ozden, GurkanPURPOSE: To examine fear of death and disruption in sleep patterns in individuals who have experienced an earthquake. METHOD: A descriptive and relationship-oriented study was performed with 322 individuals who experienced the February 6, 2023, earthquake in Turkey. Data were collected between February 20 and May 15, 2023. A personal information form, the Pittsburgh Sleep Quality Index (PSQI), and Death Anxiety Scale (DAS) were used for data collection. RESULTS: Participants'mean DAS score was 7.96 (SD = 1.05), and mean PSQI score was 8.74 (SD = 4.06). Statistically significant relationships were found between sex, marital status, and mean DAS score, and these variables accounted for 11.7% of the total variance. Similarly, statistically significant relationships were found among economic status, relationship to person trapped under the rubble, financial loss from the earthquake, and mean PSQI score, accounting for 11.3% of the total variance. Women and married people had greater fear of death, and those with good economic status, whose family members were buried under rubble, and who experienced financial loss as a result of the earthquake had lower sleep quality. CONCLUSION:The earthquake led to moderate fear of death and poor sleep quality among participants. Findings highlight the need for targeted support for vulnerable groups following disasters. [Journal ofPsychosocial Nursing and Mental Health Services, 63(2), 45-54.]Öğe Acute Appendicitis in Pregnant Women: Our Clinical Experience(Canadian Soc Clinical Investigation, 2016) Turkan, Ahmet; Yalaza, Metin; Kafadar, Mehmet Tolga; Degirmencioglu, GurkanPurpose: The purpose of this study was to analyse 13 patients who were treated in our clinic due to acute appendicitis during pregnancy. Methods: Records of the patients who received appendectomy with appendicitis diagnosis in our Turgut Ozal University Research and Application Hospital between January 2007 and December 2015 have been analyzed retrospectively. Results: Appendectomies were performed on 13 pregnant patients with an acute appendicitis diagnosis. Average age of the patients was 27.69 years (between 22-37 years). Most frequent complaint of the patients was abdominal pain and most frequent examination finding was tenderness at right lower quadrant. Ultrasonography was used in all cases for diagnosis. Surgery was decided with clinical diagnosis for five cases (38.5%) where appendix had not been identified with ultrasonography. While laparoscopic appendectomy was applied in one case (7.7%) and open appendectomy was applied using a McBurney incision in 12 cases (92.3%). Average hospitalization duration was 1.69 days. All patients were tracked together through the Gynaecology Department for two weeks after they had been discharged from the hospital. Preterm delivery, maternal and fetal loss did not occur. Conclusion: It is considered appropriate to apply ultrasonography routinely to all pregnant patients in whom acute appendicitis is suspected. Concern for maternal or fetal complication that may occur in consequence of an unnecessary surgery should not be at a level that will delay surgical treatment needed by the patient.Öğe Autonomic Cardiac Activity in Patients with Smoking and Alcohol Addiction by Heart Rate Variability Analysis(Canadian Soc Clinical Investigation, 2016) Yuksel, Ramazan; Yuksel, Rabia Nazik; Sengezer, Tijen; Dane, SenolPurpose: Smoking and alcohol addictions are common and worldwide. In the present study, we aimed to investigate the effects of these addictions on cardiac rhythm using heart rate variability (HRV) analysis. Methods: Addicts (n=42 men: 22 cigarette; 20 cigarette and alcohol) and age-matched controls (n=34 men) were included in the study. All patients fulfill the criteria for dependence according to DSM-IV-TR. Electrocardiography (ECG) recordings were obtained for a total of 30 minutes. Fagerstrom Nicotine Addiction Test (FNAT) and CAGE questionnaire (Cut down, Annoy, Guilt, Eye opener) was applied to all patients. Results: Almost all HRV parameters were significantly decreased in cigarette and cigarette and alcohol addicts compared with controls (p<0.05). The mean heart rate (bpm) increased in both addict groups compared with control group, and this increase was particularly significant in cigarette and alcohol addicts. Conclusions: The cardiac autonomic balance shifted in favor of sympathetic activity by suppressing the parasympathetic activity in addicts; therefore, the present study shows that smoking and/or alcohol addiction leads to sympathetic activation and parasympathetic inhibition. Reduced vagal activity also predisposes to cardiac arrhythmias. This suggests an increased risk of cardiovascular mortality in subjects with smoking and alcohol addiction.Öğe The Role of ADAMTS9 Gene Promoter (Ca) Repeat in Developmental Hip Dysplasia(Canadian Soc Clinical Investigation, 2015) Yilmaz, Ayse E.; Atalar, Hakan; Acar, Muradiye; Dogan, Mikail; Aytekin, Mahmut N.; Gunduz, Mehmet; Gunduz, EsraPurpose: The relationship between the number of cytosine-adenine base pair repetition [(CA)n] in the promoter zone of ADAMTS9 gene, which may affect the collagen structure, and the developmental hip dysplasia was investigated. Methods: Using DNA isolating from 26 patients diagnosed with developmental hip dysplasia (DDH) and 29 patients without DDH, the (CA) n in the promoter zone of ADAMTS9 was calculated. The distributions of groups were measured by Shapiro-Wilk test, and the average results of the groups in the state of their normal distributions were compared using parametric Student t test. Results: While the (CA) n values varied between 15 and 30, the group average was found to be 17.9. While the (CA) n values of the patient group varied between 11 and 20, its average was computed to be 17.3. The averages of groups were not statistically different (p = 0.960). Conclusion: According to the results of our study, AD-AMTS9 gene promoter (CA)n in the individuals with developmental hip dysplasia was not found to be different from that of healthy individuals. Nevertheless, when strong impact of ADAMTS9 gene on the ligament tissue is considered, it is necessary to evaluate ADAMTS9 gene role with different aspects.Öğe Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure(Canadian Soc Clinical Investigation, 2016) Aydin, Duygu; Peker, Emine G. G.; Karakurt, Meryem D.; Gurel, Ayse; Ayyildiz, Mustafa; Cevher, Sule C.; Agar, ErdalPurpose: The purpose of this study was to evaluate the efficacy of Ginkgo biloba extract (EGb 761) on oxidative events of brain in cisplatin-administrated rats. Methods: Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg intraperitoneally for 15 days, n=6); and 4) cisplatin + EGb 761 (n=6). After drug administration, rats were sacrificed and brain tissues were removed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in brain tissues. Results: Single dose cisplatin administration significantly increased NO and GSH levels, but decreased MDA levels in brain tissue samples. EGb 761 treatment reversed the effects of cisplatin on NO and GSH levels, but did not affect the decreased MDA levels. Conclusion: Results of the study indicate that oxidative stress can be an important pathogenetic mechanism of cisplatin-induced neurotoxicity. EGb 761, an standardized extract of G. biloba leaves that has antioxidant properties, may improve the oxidative stress-related neurological side effects of cisplatin.Öğe NF-?B and MAPKs are involved in resistin-caused ADAMTS-5 induction in human chondrocytes(Canadian Soc Clinical Investigation, 2015) Hatipoglu, Omer F.; Yaykasli, Kursat O.; Dogan, Mustafa; Yaykasli, Emine; Bender, Onur; Yasar, Tugce; Tapan, SafaPurpose: Chronic inflammation is an important etiological factor in the development of arthritic diseases. Several factors contribute to aggregation of chronic inflammation, including the presence of excess adipose tissue. Methods: The putative induction mechanisms of ADAMTS-5 by resistin were investigated in normal primary human articular chondrocytes. Expression levels of the ADAMTS-5 gene were determined at several resistin doses and durations. Results: Human chondrocytes were activated and associated with upregulated ADAMTS-5 gene expression after exposure to resistin (also known as adipose tissue-specific secretary factor, ADSF). Release of ADAMTS-5 leads to joint cartilage degradation, a key event in the development of arthritic diseases rheumatoid arthritis (RA) and osteoarthritis (OA). Activation of chondrocytes was associated with upregulated NF-kappa B protein levels in a time-dependent fashion. Co-incubation of human chondrocytes with JNK and p38 inhibitors lead to abrogated levels of NF-kappa B, indicating that these MAPKs are important in the activation of chondrocytes after stimulation with resistin. Similarly, ADAMTS-5 expression levels were abrogated when co-incubated with p38, NF-kappa B, JNK, MEK and PI3K inhibitors. Our results demonstrate that resistin, released from adipose tissue, may be involved in the development of RA and OA in obese patients through degradation of joint cartilage via ADAMTS-5 released from activated chondrocytes.Öğe Acoustic Source Localization in a Network of Doppler Shift Sensors(Ieee, 2013) Lindgren, David; Guldogan, Mehmet B.; Gustafsson, Fredrik; Habberstad, Hans; Hendeby, GustafIt is well-known that the motion of an acoustic source can be estimated from Doppler shift observations. It is however not obvious how to design a sensor network to efficiently deliver the localization service. In this work a rather simplistic motion model is proposed that is aimed at sensor networks with realistic numbers of sensor nodes. It is also described how to efficiently solve the associated least squares optimization problem by Gauss-Newton variable projection techniques, and how to initiate the numerical search from simple features extracted from the observed frequency series. The methods are demonstrated on real data by determining the distance to a passing propeller-driven aircraft and by localizing an all-terrain vehicle. It is concluded that the processing components included are fairly mature for practical implementations in sensor networks.Öğe Cerebral Lateralization, Depression and Serum S100B Levels in Patients with Fibromyalgia(Canadian Soc Clinical Investigation, 2015) Baygutalp, Nurcan Kilic; Yilmaz, Nurdan; Baygutalp, Fatih; Ozturk, Nurinnisa; Gul, H. Inci; Polat, Harun; Bakan, EbubekirPurpose: Fibromyalgia is a chronic pain disorder and its etiology is not well understood. Methods: The relationships among handedness score, Beck depression points and serum S100B levels in fibromyalgia patients were determined and compared between fibromyalgia patients and healthy controls. Results: The rate of left handedness was 10.81%. There were no statistically significant correlations among handedness score, Beck depression point and serum S100B level. Serum S100B levels and depression points were increased in patients with fibromyalgia compared with controls. The high S100B levels in patients with fibromyalgia may have diagnostic and prognostic value in monitoring of fibromyalgia syndromes. Conclusion: These results show that fibromyalgia syndrome is not a cerebral lateralization abnormality.
