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Öğe Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma(Ijo Press, 2016) Ergan, Esra; Ozturk, Farak; Beyazyildiz, Emrullah; Elgin, Ufuk; Sen, Emine; Cankaya, Ali Bulent; Celik, TugrulAIM: To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma. METHODS: The prospective study was composed of a study group (n=31) and a control group (a=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non -glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels. RESULTS: Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG. CONCLUSION: High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.Öğe ARRAY-CGH AND CLINICAL FINDINGS IN A PATIENT WITH A SMALL SUPERNUMERARY r(8) MOSAICISM(Medecine Et Hygiene, 2014) Eyupoglu, F. Celep; Sunnetci, D.; Cine, N.; Savli, H.; Okten, A.; Acikgoz, E. Gul; Sonmez, F. M.Array-CGH and clinical findings in a patient with a small supernumerary r(8) mosaicism: Small supernumerary ring chromosomes (sSRC) represent a subset of small supernumerary marker chromosomes (sSMC) where r(8) is relatively common. The phenotype sSRC(8) ranges from almost normal to variable degrees of abnormalities in mosaic or non-mosaic conditions. We present a new patient of de novo mosaic supernumerary ring chromosome 8 which has trisomy of a region of chromosome 8p11.21-q21.13. Mosaicism for a ring chromosome was showed by routine karyotyping that revealed a karyotype of mos47,XY,+r(?) [47]/46,XY [36] and we performed array comparative genomic hybridization (array-CGH) in order to precisely define the extension about chromosomal origin of the duplicated region in a patient. Array-CGH analysis confirmed that the sSRC derived a 43.921 Mb genomic gain of chromosome 8 (p11.21-q21.13). Common clinical features of the patient included multiple congenital anomalies, developmental delay, thoracolumbar scoliosis, mild pulmonary stenosis, laryngomalacia, hypospadias and atypical facial appearance. With this study a patient involving mosaic trisomy 8p11.21-q21.13 along with clinical properties, is described and compared to previously reported cases involving partial trisomy 8q.Öğe Does the wedge wing in the neck screw prevent cut-out failure in OTA/AO 31-A2 trochanteric fractures in elderly patients?(Acta Medica Belgica, 2014) Gunay, Cuneyd; Atalar, Hakan; Altay, Murat; Yavuz, Osman Yuksel; Yildirim, Ahmet Ozgur; Oken, Ozdamar FuadThe purpose of this retrospective study was to evaluate the effects of Dyna Locking Trochanteric (DLT) nail (U & I Corporation 529-1, Yonghyun-dong, Uijungbu Kyunggi-Do, Korea 480-050) in 31-A1 and 31-A2 intertrochanteric femur fractures. Eighty-seven patients (63 female and 24 male, mean age 77 years) were treated. The mean duration of follow-up was 16.6 +/- 3.1 months (range, 12-24 months). There were 36 cases of 31-A1 and 51 cases of 31-A2 fractures. The duration of surgery, fluoroscopy screening time, the blood loss, the hospital stay, the tip-apex distance were significantly less in the 31-A1 fracture group compared with the 31-A2 fracture group (p < 0.001). Cut-out was observed in 13 patients (14.9%) above 80 years old with 31-A2 fractures. Especially in elderly patients with unstable 31-A2 fractures, the wedge wing on the neck screw does not work properly. Therefore further biomechanical investigations and also prospective clinical studies with larger series are needed to improve the device.Öğe PHACOMATOSIS PIGMENTOVASCULARIS TYPE IIB ASSOCIATED WITH STURGE-WEBER SYNDROME: A CASE REPORT AND REVIEW OF THE LITERATURE(Medecine Et Hygiene, 2013) Sonmez, F. M.; Aksoy, A.; Sari, A.; Erpolat, S.; Ozkaya, A. K.[Abstract Not Available]Öğe The roles of Klotho and FGF-23 in bipolar manic episode(Verduci Publisher, 2023) Emir, B. Sirlier; Yildiz, S.; Kilicaslan, A. Kazgan; Kilic, F.; Ugur, K.; Aydin, S.; Atmaca, M.OBJECTIVE: Bipolar disorder (manic episode) is an essential psychiatric disorder with unknown etiology, in which inflammation is considered to play a role. Klotho and FGF-23 are known to be associated with inflammation. Therefore, this study aimed to determine the link between Klotho and FGF-23 levels and bipolar disorder. PATIENTS AND METHODS: In this study, 42 men with BD and 41 healthy controls were enrolled, followed up, and/or treated at the High-Security Forensic Psychiatry Clinic. Sociodemographic data form, Young Mania Rating Scale, and Hamilton Depression Rating Scale were applied to all participants. RESULTS: Klotho and FGF-23 levels were significantly increased in patients with BD manic episodes. There was no correlation between Klotho and FGF-23 levels and clinical parameters. For Klotho and FGF-23, cutoff values of 69 and 1,646 yielded 67.4% sensitivity and 72.1% specificity and 81.4% sensitivity and 51.2% specificity, respectively. CONCLUSIONS: Klotho and FGF-23 may play critical roles in the etiopathology of manic episodes and are potential candidate biomarkers for bipolar disorder. This relationship might contribute to the etiopathogenesis of the disease and determine its treatment. Anti-Klotho and anti-FGF-23 administration may be a future treatment for controlling the course of the disease.Öğe Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?(Canadian Soc Clinical Investigation, 2016) Selcoki, Yusuf; Aydin, H. Ibrahim; Celik, Tugrul H.; Isleyen, Ahmet; Erayman, Ali; Demircelik, M. Bora; Demirin, HilmiPurpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age-and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2 +/- 3.0 mm vs. 39.6 +/- 3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p = 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.Öğe Teething and affecting factors: experiences from Turkey(Edizioni Minerva Medica, 2016) Yilmaz, Ayse E.; Dogan, Guzide; Akelma, Ahmet Z.; Karabel, Musemma; Karabel, Duran; Akca, Halise; Erdur, Emire A.BACKGROUND: The aim of this study was to investigate the experiences of Turkish mothers in teething period and the factors affecting teething. METHODS: This study was performed by filling in questionnaire forms with a face-to-face interview technique with the mothers of 792 patients presenting to the outpatient clinics of pediatrics of Fatih (Turgut Ozal) University Faculty of Medicine between 1 April and 31 July 2012. RESULTS: This study was conducted in a total of 792 children (mean age: 24.2 +/- 7.9, range 12-42 months; 430 males). Of the study population, 6.1% had a family history of premature teething, 9.7% had a family history of delayed teething, 98% had been breastfed, 91.9% had used vitamin D, 67.6% had used iron supplements, and 3.9% had fluorine use. The first teething was at 7.8 +/- 2.5 months and the first teeth to appear was the anterior lower incisor (58.7%). The symptoms the patients had during teething were irritability (64.9%), fever (64.1%), increased mastication (61.6%), increased salivation (58.2%), and diarrhea (45.6%). The rate of admission to a physician with these complaints was 19.6%. The factors affecting the teething time were a family history of premature or delayed teething and birth with natal tooth, and male gender. CONCLUSIONS: In this study we found that nutritional or local factors were not effective on teething time. Teething period was characterized by nonspecific symptoms including irritability, subfebrile fever, increased mastication and salivation, and diarrhea. Linear regression analysis revealed that male gender and a family history of premature teething were the factors responsible from a shortening in teething time.Öğe Fear of Death and Sleep Quality in the Aftermath of an Earthquake(Slack Inc, 2025) Aktura, Seher Cevik; Celik, Hanife; Saritas, Seyhan Citlik; Ozden, GurkanPURPOSE: To examine fear of death and disruption in sleep patterns in individuals who have experienced an earthquake. METHOD: A descriptive and relationship-oriented study was performed with 322 individuals who experienced the February 6, 2023, earthquake in Turkey. Data were collected between February 20 and May 15, 2023. A personal information form, the Pittsburgh Sleep Quality Index (PSQI), and Death Anxiety Scale (DAS) were used for data collection. RESULTS: Participants'mean DAS score was 7.96 (SD = 1.05), and mean PSQI score was 8.74 (SD = 4.06). Statistically significant relationships were found between sex, marital status, and mean DAS score, and these variables accounted for 11.7% of the total variance. Similarly, statistically significant relationships were found among economic status, relationship to person trapped under the rubble, financial loss from the earthquake, and mean PSQI score, accounting for 11.3% of the total variance. Women and married people had greater fear of death, and those with good economic status, whose family members were buried under rubble, and who experienced financial loss as a result of the earthquake had lower sleep quality. CONCLUSION:The earthquake led to moderate fear of death and poor sleep quality among participants. Findings highlight the need for targeted support for vulnerable groups following disasters. [Journal ofPsychosocial Nursing and Mental Health Services, 63(2), 45-54.]Öğe Autonomic Cardiac Activity in Patients with Smoking and Alcohol Addiction by Heart Rate Variability Analysis(Canadian Soc Clinical Investigation, 2016) Yuksel, Ramazan; Yuksel, Rabia Nazik; Sengezer, Tijen; Dane, SenolPurpose: Smoking and alcohol addictions are common and worldwide. In the present study, we aimed to investigate the effects of these addictions on cardiac rhythm using heart rate variability (HRV) analysis. Methods: Addicts (n=42 men: 22 cigarette; 20 cigarette and alcohol) and age-matched controls (n=34 men) were included in the study. All patients fulfill the criteria for dependence according to DSM-IV-TR. Electrocardiography (ECG) recordings were obtained for a total of 30 minutes. Fagerstrom Nicotine Addiction Test (FNAT) and CAGE questionnaire (Cut down, Annoy, Guilt, Eye opener) was applied to all patients. Results: Almost all HRV parameters were significantly decreased in cigarette and cigarette and alcohol addicts compared with controls (p<0.05). The mean heart rate (bpm) increased in both addict groups compared with control group, and this increase was particularly significant in cigarette and alcohol addicts. Conclusions: The cardiac autonomic balance shifted in favor of sympathetic activity by suppressing the parasympathetic activity in addicts; therefore, the present study shows that smoking and/or alcohol addiction leads to sympathetic activation and parasympathetic inhibition. Reduced vagal activity also predisposes to cardiac arrhythmias. This suggests an increased risk of cardiovascular mortality in subjects with smoking and alcohol addiction.Öğe Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure(Canadian Soc Clinical Investigation, 2016) Aydin, Duygu; Peker, Emine G. G.; Karakurt, Meryem D.; Gurel, Ayse; Ayyildiz, Mustafa; Cevher, Sule C.; Agar, ErdalPurpose: The purpose of this study was to evaluate the efficacy of Ginkgo biloba extract (EGb 761) on oxidative events of brain in cisplatin-administrated rats. Methods: Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg intraperitoneally for 15 days, n=6); and 4) cisplatin + EGb 761 (n=6). After drug administration, rats were sacrificed and brain tissues were removed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in brain tissues. Results: Single dose cisplatin administration significantly increased NO and GSH levels, but decreased MDA levels in brain tissue samples. EGb 761 treatment reversed the effects of cisplatin on NO and GSH levels, but did not affect the decreased MDA levels. Conclusion: Results of the study indicate that oxidative stress can be an important pathogenetic mechanism of cisplatin-induced neurotoxicity. EGb 761, an standardized extract of G. biloba leaves that has antioxidant properties, may improve the oxidative stress-related neurological side effects of cisplatin.Öğe The Effect of Coasting on Intracytoplasmic Sperm Injection Outcome in Antagonist and Agonist Cycle(Royan Inst, 2017) Duvan, Z. Candan Iltemir; Kalem, Muberra Namli; Onaran, Yuksel; Keskin, Esra Aktepe; Ayrim, Aylin; Pekel, Aslihan; Kafali, HasanBackground: Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. Materials and Methods: In a retrospective cohort study, 117 ICSI cycles were performed and coasting was applied due to hyperresponse, between 2006 and 2011. The ICSI outcomes after coasting were then compared between the GnRH agonist group (n=91) and the GnRH antagonist group (n=26). Results: The duration of induction and the total consumption of gonadotropins were found to be similar. Estradiol (E-2) levels on human chorionic gonadotropin (hCG) day were found higher in the agonist group. Coasting days were similar when the two groups were compared. The number of mature oocytes and the fertilization rates were similar in both groups; however, the number of grade 1 (G1) embryos and the number of transferred embryos were higher in the agonist group. Implantation rates were significantly higher in the antagonist group compared to the agonist group. Pregnancy rates/embryo transfer rates were higher in the antagonist group; however, this difference was not statistically significant (32.8% for agonist group vs. 39.1% for antagonist group, P > 0.05). Conclusion: The present study showed that applying GnRH-agonist and GnRH-antagonist protocols to coasted cycles did not result in any differences in cycle parameters and clinical pregnancy rates.Öğe Maternal Height and Infant Body Mass Index Are Possible Risk Factors for Developmental Dysplasia of the Hip in Female Infants(Okayama Univ Med School, 2015) Atalar, Hakan; Gunay, Cuneyd; Yavuz, Osman Yuksel; Camurdan, Aysu Duyan; Uras, Ismail; Eren, AliDevelopmental dysplasia of the hip (DDH) is a wide-spectrum disease with a multifactorial etiology and, despite its prevalence, no definitive etiology has yet been established. The aim of this study was to investigate new risk factors for DDH by evaluating newly defined potential risk factors. A total of 71 infants were separated into 2 groups: Group 1, 28 female first-born infants diagnosed with DDH and their mothers; and Group II, 43 healthy female first-born infants and their mothers. The maternal height and weight before pregnancy, infant height and weight at birth, and body mass index (BMI) of both mother and infant were determined. Calculations were made of the ratios between these parameters. Of the examined risk factors, only maternal height and the ratio of maternal height to infant BMI (MH/I-BMI) were found to be significant for DDH in infants. In conclusion, the results of this study show that a short maternal height and a low MH/I-BMI increase the risk of DDH. Further studies with a larger series are necessary to confirm these results.Öğe HIGH RISK OF INTERNET ADDICTION AND ITS RELATIONSHIP WITH LIFETIME SUBSTANCE USE, PSYCHOLOGICAL AND BEHAVIORAL PROBLEMS AMONG 10th GRADE ADOLESCENTS(Medicinska Naklada, 2014) Evren, Cuneyt; Dalbudak, Ercan; Evren, Bilge; Demirci, Arzu CiftciBackground: The aim of this study was to investigate the relationship of higher risk of Internet addiction (HRIA) with lifetime substance use, psychological and behavioral factors among Turkish 10th grade students. Subjects and methods: Cross-sectional online self-report survey conducted in 45 schools from the 15 districts in Istanbul, Turkey. A representative sample of 4957 10th grade students was studied between October 2012 and December 2012. Other than sociodemographic variables the survey included the Addiction Profile Index Internet Addiction Form-Screening Version (BAPINTSV) and the Psychological Screening Test for Adolescents (PSTA). Results: The participants were classified into two groups as those with HRIA (15.96%) and those with lower risk of Internet addiction. The rate of HRIA was higher in the males. The findings indicated that HRIA is related with negative consequences in school, lifetime use of tobacco, alcohol and/or drug, suicidal thoughts, self-harming and delinquent behaviors. Conclusions: Male gender, lifetime use of tobacco, alcohol and/or drug, depression, attention deficit and hyperactivity symptoms and lack of assertiveness predicted the HRIA in Turkish 10th grade students. Being aware of those with HRIA is important in prevention and management of Internet addiction as well as other important problems among students, such as substance use.Öğe Sleep quality and glycemic control in children and adolescents with type 1 diabetes mellitus(Verduci Publisher, 2023) Berk, E.; Celik, N.OBJECTIVE: This study aimed to investigate the frequency of sleep disorders, and the relationship between glycemic control and sleep characteristics in diabetic children and adolescents. PATIENTS AND METHODS: Sixty-one patients followed for at least one year for type 1 diabetes mellitus (T1DM) aged 6-16 years old, and eighty-three group-matched healthy controls were included in the study. Time in range (TIR) and hypoglycemia episode numbers were recorded using the freestyle libre sensor data. The sleep characteristics were evaluated using the Sleep Disturbance Scale for Children (SDSC) validated survey. The diabetic patients were tri-chotomized according to SDSC scores, as low, medium, and high score groups. RESULTS: Sleep duration, SDSC total score, and subgroup scores except for sleep hyperhidrosis (3.11 +/- 1.53 vs. 2.16 +/- 0.85, p<0.001, respectively) were similar (p>0.05) between the diabetic and control group. According to the survey, 1.6% of diabetic cases and 6.1% of the control group had clinically significant sleep disturbances (p>0.05). Duration of diabetes (DD) was lower (p=0.01), and the level of HbA1C was higher (p=0.02) in the high-score group than the others. Regression analysis revealed that TIR was the only independent determinant for the SDSC score (beta=-1.27, t=-1.90; p=0.012). CONCLUSIONS: Sleep habits and problems should be routinely evaluated in diabetic children and adolescents.Öğe Can myocardial dysfunction be detected in patients with rheumatoid arthritis with no cardiac symptoms?(Verduci Publisher, 2023) Akgol, G.; Gulkesen, A.; Uslu, E. Y.; Alkan, G.; Bolayir, H. A.; Gelen, M. A.; Uslu, M. F.OBJECTIVE: The aim of our study was to investigate the role of tissue Dop-pler and Myocardial Performance Index (MPI) in evaluating cardiac involvement in patients with rheumatoid arthritis (RA) with no cardi-ac symptoms, to determine whether these mea-surements differ between healthy controls and RA patients, and whether they can be used to determine the risk of cardiovascular disease and predict prognosis.PATIENTS AND METHODS: 50 RA patients fulfilling the 2010 American College of Rheuma-tology/European League Against Rheumatism (ACR/EULAR) RA criteria and 50 healthy volun-teering controls were included in the study. All patients and controls were assessed using elec-trocardiography (ECG), echocardiography, con-ventional Doppler echocardiography and tissue Doppler echocardiography. MPI values were cal-culated. In addition, RA patients were compared after being divided into two subgroups: sero-positive and seronegative RA. Disease activi-ty levels of the patients were determined based on Disease Activity Score in 28 Joints (DAS28).RESULTS: The control group and RA group were compared in terms of PR interval, left atrial diameter, E/A, E/e', and MPI values. Comparisons between the groups yielded statistically signifi-cant differences in left atrial diameter, E/A, E/e', and MPI values and no significant difference in PR intervals. These parameters were also com-pared between seropositive and seronegative pa-tients. Left atrial diameter was significantly high-er in seronegative patients than in seropositive patients. There was no significant difference in the other values. DAS28 scores had no correla-tion with cardiac parameters.CONCLUSIONS: Early detection of ventricu-lar dysfunction in RA may be useful in clinical practice when predicting prognosis and optimiz-ing treatment. The present study found that RA patients had impaired tissue Doppler measure-ments and MPI results compared to controls. MPI and tissue Doppler may be useful in early detection of ventricular dysfunction.Öğe Comparing the effectiveness of prolotherapy and percutaneous dry needling in the treatment of lateral epicondylitis: a retrospective cohort study(Verduci Publisher, 2023) Boz, M.; Sahin, A. A.OBJECTIVE: Lateral epicondyli-tis (LE) can result in a functional loss in patients because of pain and has recently become more prevalent. This study compared the effects of minimally invasive prolotherapy (PRO) and per -cutaneous dry needling (PDN) on LE treatment. PATIENTS AND METHODS: Patients were di-vided into three groups; Group 1 included pa-tients undergoing PDN, Group 2 included those undergoing PRO, and Group 3 included those undergoing PDN+PRO. All these treatments were administered three times and at a 3-week interval in each patient. Data on the visual ana-log scale (VAS) and patient-rated tennis elbow evaluation (PRTEE) scale scores of the patients were collected at weeks 0, 3, and 6 and month 6 and retrospectively analyzed.RESULTS: The VAS and PRTEE scores de-creased in all groups. The decrease in Group 3 was higher than that in the other groups (p<0.001). Upon evaluating within-group differences in VAS and PRTEE scores, the scores at week 3, week 6, and month 6 gradually decreased compared with the baseline in all groups (p<0.001). CONCLUSIONS: PDN and PRO are minimally invasive and can successfully treat LE. A combi-nation of PDN+PRO provides better results than PDN or PRO alone. As the materials we used in these treatments are relatively inexpensive and readily available, we believe our study will help reduce the national healthcare costs allocated for the treatment of LE.Öğe Neutrophil-Lymphocyte Ratio (NLR) Could Be Better Predictor than C-reactive Protein (CRP) for Liver Fibrosis in Non-alcoholic Steatohepatitis(NASH)(Assoc Clinical Scientists, 2015) Yilmaz, Hakki; Yalcin, Kadir Serkan; Namuslu, Mehmet; Celik, Huseyin Tugrul; Sozen, Meral; Inan, Osman; Nadir, IsilayBackground-Aim. Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide. The aims of this study were to assess Neutrophil-Lymphocyte Ratio (NLR) and C-reactive protein (CRP), and their association with liver histology in patients with non-alcoholic steatohepatitis (NASH), chronic hepatitis B (HBV), and hepatitis C (HCV). Material-Methods. We studied 38 consecutive patients with biopsy-proven NASH, 19 patients with HCV, 45 patients with HBV, and 35 healthy controls who were similar for age and gender. The stage of fibrosis was measured using a 6-point scale. Results. NLR was significantly higher in NASH patients compared to controls, HBV, and HCV patients (p<0.001, p<0.001, and p<0.001, respectively). NLR was positively associated with NAFLD activity scores (r=0.861, p<0.001). NLR was associated with hepatocyte ballooning degeneration (r=0.426, p=0.024), lobular inflammation(r=0.694, p<0.001), steatosis(r=0.498, p=0.007), and fibrosis stage(r=0.892, p<0.001) in NASH patients. Univariate and multivariate analyses showed that NLR was significantly associated with liver fibrosis and NAS (beta=0.631, p<0.001 for liver fibrosis; beta=0.753, p<0.001 for NAS in the multivariate model); however, CRP had no association with liver fibrosis and NAS. Conclusion. NLR is a promising and inexpensive inflammation marker that correlates with histological grade and fibrosis stage in NASH patients.Öğe Multiple factors influencing mortality in hemodialysis patients(Verduci Publisher, 2023) Yaprak, B.; Arslan, N.; Alatas, H.OBJECTIVE: Both decreased food intake and elevated inflammation contribute to malnutrition in hemodialysis (HD) patients. Malnutrition, inflammation, anthropometric measurements, and other comorbidity factors were investigated in this study as potential indicators of mortality in HD patients.PATIENTS AND METHODS: By measuring geriatric nutritional risk index (GNRI), malnutrition inflammation score (MIS), and prognostic nutritional index (PNI), 334 HD patients' nutritional status was assessed. Through the use of four different models and logistic regression analysis, the predictors of each individual's survival status were examined. The models were matched using the Hosmer-Lemeshow test. On the survival of patients, the effects of malnutrition indices in Model 1, anthropometric measurements in Model 2, blood parameters in Mod-el 3, and sociodemographic characteristics in Model 4 were investigated.RESULTS: Five years later, 286 individuals were still on hemodialysis. Patients who had a high GNRI value had a lower mortality rate in Model 1. The body mass index (BMI) value of the patients was found to be the best predictor of mortality in Model 2, and it was found that patients with high muscle percentage had a lower mortality risk. The difference in urea level measured at the beginning and end of hemodialysis was found to be the most potent predictor of mortality in Model 3, although C-reactive protein (CRP) level was also discovered to be one of the best predictors for this model. The final model, Model 4, revealed that mortality was low-er in women than in men and that income status was a reliable predictor of mortality estimation.CONCLUSIONS: The best indicator of mortality in hemodialysis patients is the malnutrition index.Öğe The effects of hypericin on ADAMTS and p53 gene expression in MCF-7 breast cancer cells(Imprimatur Publications, 2014) Acar, Muradiye; Ocak, Zeynep; Erdogan, Kubra; Cetin, Elif Nihan; Hatipoglu, Omer Faruk; Uyeturk, Ummugul; Gunduz, EsraPurpose: The purpose of this study was to determine the effects of hypericin on MCF-7 (Michigan Cancer Foundation-7) breast cancer cells, as it is known to exert an antitumor effect on the expression and regulation of ADAMTS1, 3, 10 and the p53 gene in breast cancer cells. Methods: MFC-7 cells were cultured and subjected separately to various doses (1, 5 and 7.5 mu g/mL) hypericin. After 24 hrs, RNA was isolated and transcribed into cDNA. Expression analysis was performed by real time (RT)-PCR and cell survival was determined by the XTT assay. Results: While the expression of ADAMTS1 in MFC-7 cells decreased to 0.04-fold after exposure to 1 mu g/mL hypericin, the expression increased by 5.6- and 36-fold with 5 and 7.5 mu g/mL, respectively. Furthermore, ADAMTS3 expression in MCF7 cells increased 3.9-fold with the use of 5 mu g/mL of hypericin. These concentrations of hypericin did not lead to significant changes in the expression of ADAMTS10 and the p53 gene. Viability of cancer cells as evaluated by the XTT assay showed that hypericin concentration of 7.5 mu g/mL led to increased apoptosis of cancer cells. Conclusion: The increase in ADAMTS1 expression may prevent metastasis or facilitate the development of an adjuvant factor with tumor-suppressive effects. Hypericin may therefore exert its antitumor and apoptotic effects in MFC-7 cells via ADAMTS1 and ADAMTS3.Öğe The relationship between the use of nucleos(t)ide analogs and metabolic parameters in patients with chronic hepatitis B(Verduci Publisher, 2023) Yakut, A.; Aladag, M.OBJECTIVE: In the treatment of chronic hepatitis-B (CHB), although viral rep-lication load is reduced with the use of nucle-os(t)ide analogs, the risk of cirrhosis and hepa-tocellular carcinoma (HCC) remains. We aimed to investigate the relationship between metabol-ic syndrome (MetS) and CHB of nucleos(t)ide an-alogs, which are effective in mortality-morbidity. PATIENTS AND METHODS: In patients who applied to the gastroenterology outpatient clin-ic between 2021 and 2022, we compared inac-tive HBsAg-positive patients who did not receive treatment with nucleos(t)ide analogs [entecavir (ETV), lamivudine (LAM), tenofovir disoproxil fu-marate (TDF), tenofovir alafenamide (TAF)] and medical treatment. Demographic characteristics of the patients were recorded. Lipid profile, He-moglobin A1c (HbA1c), and HOMA-IR were re-corded. The presence of hepatosteatosis was graded ultrasonographically. APRI, Forns Index, and FIB-4 score, which are indicators of non-in-vasive liver fibrosis, were evaluated. RESULTS: Of the 265 patients, 55.5% (n=147) were males and 44.5% (n=118) were females. The ages of the participants ranged from 18 to 80, with a mean age of 46.54 +/- 14.03. It was observed that 62.3% (n=165) of the cases received medical treat-ment. When the drugs used by those receiving medical treatment were examined, 70.3% (n=116) TDF, 6.1% (n=10) TAF, 3% (n=5) LAM, and 20.6% (n=34) ETV, LDL, HDL, and total cholesterol mea-surement values of those who received medical treatment were lower, while HOMA-IR values were higher compared to those who did not receive the medical treatment. While the HbA1c value of the patients using ETV was found to be high, the liv-er stiffness indicator scores of those using TDF were found to be significantly higher. CONCLUSIONS: In this study, in patients with CHB, it has been shown that medical treatment also affects MetS parameters.
