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Öğe Effect of sleep hygiene education on sleep quality in patients with liver transplantation(Wolter Kluwer, 2022) Demir, BilsevThis study aimed to determine the effects of sleep hygiene education on sleep quality in liver transplant patients. In the literature, the efficacy of various pharmacological methods for reducing poor sleep quality associated with liver transplant patients and studies on nonpharmacological methods are limited. This study was conducted using a quasiexperimental design with a pre- and posttest, and a control group. When the power analysis was made, a sample size with 5% double-sided significance, 95% confidence interval, and 95% ability to represent the population was calculated to have a total of 100 liver transplant patients. The data were collected using a patient information form, and the Richard Campbell Sleep Quality Questionnaire. In the experimental group, the researcher gave a sleep hygiene training for 1 week. No treatment was performed in the control group. To analyze the data, descriptive statistics, a chi(2) test, a t test for dependent groups, and a t test for independent groups were used. According to sleep hygiene training follow-ups after liver transplantation, the mean scores of sleep quality was similarly poor, with a statistical significance in the experimental group compared with the control group in all measurements before and after sleep hygiene training (P < .001). The sleep hygiene training applied to liver transplant patients positively affected and decreased the severity of sleep quality.Öğe Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation(Murat Aladag, 2021) Mesut Akarsu; Soner Onem; Ilker Turan; Gupse Adali; Meral Akdogan; Murat Akyildiz; Murat Aladag; Yasemin Balaban; Nilay Danis; Murat Dayangac; Genco Gencdal; Hale Gokcan; Elif Sertesen; Merve Gurakar; Murat Harputluoglu; Gokhan Kabacam; Sedat Karademir; Murat Kiyici; Ramazan Idilman; Zeki KarasuThe combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation.Öğe Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey(Pembegul, Irem, 2020) Savas Ozturk; Kenan Turgutalp; Mustafa Arici; Ali Riza Odabas; Mehmet Riza Altiparmak; Zeki Aydin; Egemen Cebeci; Taner Basturk; Zeki Soypacaci; Garip Sahin; Tuba Elif Ozler; Ekrem Kara; Hamad Dheir; Necmi Eren; Gultekin Suleymanlar; Mahmud Islam; Melike Betul Ogutmen; Erkan Sengul; Yavuz Ayar; Murside Esra Dolarslan; Serkan Bakirdogen; Seda Safak; Ozkan Gungor; Idris Sahin; Ilay Berke Mentese; Ozgur Merhametsiz; Ebru Gok Oguz; Dilek Gibyeli Genek; Nadir Alpay; Nimet Aktas; Murat Duranay; Selma Alagoz; Hulya Colak; Zelal Adibelli; Irem Pembegul; Ender Hur; Alper Azak; Dilek Guven Taymez; Erhan Tatar; Rumeyza Kazancioglu; Aysegul Oruc; Enver Yuksel; Engin Onan; Kultigin Turkmen; Nuri Baris Hasbal; Ali Gurel; Berna Yelken; Tuncay Sahutoglu; Mahmut Gok; Nurhan Seyahi; Mustafa Sevinc; Sultan Ozkurt; Savas Sipahi; Sibel Gokcay Bek; Feyza Bora; Bulent Demirelli; Ozgur Akin Oto; Orcun Altunoren; Serhan Zubeyde Tuglular; Mehmet Emin Demir; Mehmet Deniz Ayli; Bulent Huddam; Mehmet Tanrisev; Ilter Bozaci; Meltem Gursu; Betul Bakar; Bulent Tokgoz; Halil Zeki Tonbul; Alaattin Yildiz; Siren Sezer; Kenan AtesBackground Chronic kidney disease (CKD) and immunosuppression, such as in renal transplantation (RT), stand as one of the established potential risk factors for severe coronavirus disease 2019 (COVID-19). Case morbidity and mortality rates for any type of infection have always been much higher in CKD, haemodialysis (HD) and RT patients than in the general population. A large study comparing COVID-19 outcome in moderate to advanced CKD (Stages 3–5), HD and RT patients with a control group of patients is still lacking. Methods We conducted a multicentre, retrospective, observational study, involving hospitalized adult patients with COVID-19 from 47 centres in Turkey. Patients with CKD Stages 3–5, chronic HD and RT were compared with patients who had COVID-19 but no kidney disease. Demographics, comorbidities, medications, laboratory tests, COVID-19 treatments and outcome [in-hospital mortality and combined in-hospital outcome mortality or admission to the intensive care unit (ICU)] were compared. Results A total of 1210 patients were included [median age, 61 (quartile 1–quartile 3 48–71) years, female 551 (45.5%)] composed of four groups: control (n = 450), HD (n = 390), RT (n = 81) and CKD (n = 289). The ICU admission rate was 266/1210 (22.0%). A total of 172/1210 (14.2%) patients died. The ICU admission and in-hospital mortality rates in the CKD group [114/289 (39.4%); 95% confidence interval (CI) 33.9–45.2; and 82/289 (28.4%); 95% CI 23.9–34.5)] were significantly higher than the other groups: HD = 99/390 (25.4%; 95% CI 21.3–29.9; P?Öğe COVID-CCD-Net: COVID-19 and colon cancer diagnosis system with optimized CNN hyperparameters using gradient-based optimizer(Malatya Turgut Özal Üniversitesi, 2022) Sert,Eser; Kızıloluk,SonerCoronavirus disease-2019 (COVID-19) is a new types of coronavirus which have turned into a pandemic within a short time. Reverse transcription-polymerase chain reaction (RT-PCR) test is used for the diagnosis of COVID-19 in national healthcare centers. Because the number of PCR test kits is often limited, it is sometimes difficult to diagnose the disease at an early stage. However, X-ray technology is accessible nearly all over the world, and it succeeds in detecting symptoms of COVID-19 more successfully. Another disease which affects people's lives to a great extent is colorectal cancer. Tissue microarray (TMA) is a technological method which is widely used for its high performance in the analysis of colorectal cancer. Computer-assisted approaches which can classify colorectal cancer in TMA images are also needed. In this respect, the present study proposes a convolutional neural network (CNN) classification approach with optimized parameters using gradient-based optimizer (GBO) algorithm. Thanks to the proposed approach, COVID-19, normal, and viral pneumonia in various chest X-ray images can be classified accurately. Additionally, other types such as epithelial and stromal regions in epidermal growth factor receptor (EFGR) colon in TMAs can also be classified. The proposed approach was called COVID-CCD-Net. AlexNet, DarkNet-19, Inception-v3, MobileNet, ResNet-18, and ShuffleNet architectures were used in COVID-CCD-Net, and the hyperparameters of this architecture was optimized for the proposed approach. Two different medical image classification datasets, namely, COVID-19 and Epistroma, were used in the present study. The experimental findings demonstrated that proposed approach increased the classification performance of the non-optimized CNN architectures significantly and displayed a very high classification performance even in very low value of epoch.Öğe Sinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkey(King Faisal Specialist Hospital and Research Centre, 2022) Acun Delen, Leman; Öterkuş, MesutBACKGROUND: The Alpha variant of SARS-CoV-2 has a higher transmission rate than the first variant identified. The efficacy of vaccines is affected by the characteristics of SARS-CoV-2 variants. OBJECTIVE: Investigate the relationship of vaccination and virus variant on the course of the disease in patients who were hospitalized with a diagnosis of COVID-19. DESIGN: Retrospective, cohort study SETTING: Tertiary health institution PATIENTS AND METHODS: The study included patients older than the age of 18 years who were hospitalized in a COVID-19 service or the intensive care unit with a diagnosis of COVID-19 between 1 January 2021 and 30 April 2021. Demographic characteristics, vaccination and the Alpha virus variant status, comorbidities, and information about hospitalization were obtained from the hospital automation system and patient files. MAIN OUTCOME MEASURES: Vaccination rate and relationship with course of disease. SAMPLE SIZE: 608 RESULTS: Most of the patients (n=482, 79.3%) were admitted to the COVID-19 service. More of the COVID-19 service patients had the Alpha variant than the patients admitted to ICU (P<.009). The Alpha variant was also more common in younger patients (P<.001). There was no relationship between the Alpha virus and comorbid diseases such as diabetes mellitus and hypertension. Mortality was lower in the patients who had received a second dose of the Sinovac vaccine (P=.004) compared with unvaccinated patients. CONCLUSION: Although the Alpha variant spreads faster, it has a milder course. If only the Sinovac vaccine is available, we recommend that the two doses of the Sinovac vaccine be administered. LIMITATIONS: Our study is single-center and did not include pregnant and pediatric patients. CONFLICT OF INTEREST: None.Öğe Deep learning model developed by multiparametric MRI in differential diagnosis of parotid gland tumors(Springer, 2022) Gündüz, Emrah; Alçin, Ömer Faruk; Kızılay, Ahmet; Yıldırım, İsmail OkanPurpose: To create a new artificial intelligence approach based on deep learning (DL) from multiparametric MRI in the differential diagnosis of common parotid tumors. Methods: Parotid tumors were classified using the InceptionResNetV2 DL model and majority voting approach with MRI images of 123 patients. The study was conducted in three stages. At stage I, the classification of the control, pleomorphic adenoma, Warthin tumor and malignant tumor (MT) groups was examined, and two approaches in which MRI sequences were given in combined and non-combined forms were established. At stage II, the classification of the benign tumor, MT and control groups was made. At stage III, patients with a tumor in the parotid gland and those with a healthy parotid gland were classified. Results: A stage I, the accuracy value for classification in the non-combined and combined approaches was 86.43% and 92.86%, respectively. This value at stage II and stage III was found respectively as 92.14% and 99.29%. Conclusions: The approach presented in this study classifies parotid tumors automatically and with high accuracy using DL models.Öğe Levels of metals and elements in tissues of fish species in the Kızılırmak River (Turkey) and assessment of health risks and nutritional benefits(Elsevier, 2022) Varol, Memet; Kaçar, Emel; Sünbül, Muhammet Raşit; Md Towfiqul Islam, Abu RezaAlthough the Kızılırmak River, the longest river in Turkey, is home to many fish species, there are a few studies reporting metal levels in fish in the river. The contents of 17 metals and elements (MEs) in various tissues of three fish species and surface water from the river were investigated. Significant differences in the ME levels among tissues were recorded, and the highest levels of most MEs were recorded in the gills and liver. The results revealed that correlations between MEs in tissues and fish size were not clear and consistent. Among the MEs, P (6058–109489) and Zn (933–47556) had the highest bioconcentration factor values. The levels of As and Cd in the river water exceeded water quality criteria. Health risk assessment methods (Target Hazard Quotient, Estimated Daily Intake and Lifetime Carcinogenic Risk) indicated that consumption of the studied fish species is safe. It was estimated that a weekly consumption of 490 g of C. gibelio, or 350 g of C. carpio or 280 g of T. tinca would not cause any health risks. Furthermore, it was found that fish species would provide significant benefits in terms of intake of nutrients such as P, K, Ca, Mg, Cu, Zn, Fe and Mn. These findings revealed that nutritional benefits from consumption of fish species outweigh the health risks posed by metals in fish.Öğe Evaluation of the relationship between nasal septal deviation and development of facial asymmetry with anthropometric measurements depending on age: The effect of nasal septum deviation on craniofacial asymmetry and somatotype(Elsevier, 2022) Arpacı, Muhammed Furkan; Özbağ, Davut; Aydın, Şükrü; Şenol, Deniz; Baykara, Rabia Aydoğan; Çiçek, İpek BalıkçıAim: It was aimed to determine the change of facial asymmetry resulting from nasal septal deviation (SD) depending on age, gender, degree of deviation and the affected area besides the effect of SD on somatotype and craniofacial morphology. Materials and methods: 171 volunteers (90 males, 81 females), 27 individuals aged 9–13, 44 individuals aged 14–18, 44 individuals aged 19–23 and 56 individuals in control group participated in the study conducted in otorhinolaryngology polyclinic.11 photometric, 16 anthropometric measurements were taken from the participants. Results: SD affects facial asymmetry formation, although not statistically significant compared to healthy individuals asymmetry rates (p?0.05). It was determined that the degree of SD affected asymmetry only between the ages of 14–18 (in adolescence) and the development of asymmetry in all SD patients was not statistically dependent on age and gender (p?0.05). Photometric measurements demonstrated asymmetries in horizontally-extending parameters of 1/3 middle part of face. There was no statistically significant difference in the cranial anthropometric measurements of the upper and lower 1/3 of the face compared to the control group (p?0.05). The order of the most asymmetrical parameters is Alare-Zygion, Alare-Subnasale, Cheilion-Gonion, Exocanthion-Cheilion, Midsagittal plane-Zygion, Zygion-Cheilion, Zygion-Gonion, Subalare-Cheilion, Glabella-Exocanthion. In all participants were determined that endomorph somatotype was dominant in female and mesomorph somatotype was dominant in male besides SD did not affect somatotype and somatotype did not alter with age. Conclusion: The development of facial asymmetry due to SD is not affected by age and gender furthermore SD does not affect craniofacial asymmetry and somatotype.Öğe Clinical and Molecular Findings in a Turkish Family Who Had a (c.869-1G>A) Splicing Variant in PSEN1 Gene with A Rare Condition: The Variant Alzheimer's Disease with Spastic Paraparesis(Bentham Science, 2022) Doğan, Mustafa; Eröz, Recep; Tecellioğlu, Mehmet; Gezdirici, Alper; Çevik, Betül; Barış, İbrahimBackground: Early-onset Alzheimer's disease (EOAD) is commonly diagnosed with an onset age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases. To date, although only 10-15% of familial EOAD cases have been explained, the genetic cause of the vast proportion of cases has not been explained. The variant Alzheimer's disease with spastic paraparesis (var- AD) is defined as a rare clinical entity characterized by early-onset dementia, spasticity of the lower extremities, and gait disturbance. Although the disease was first associated with variants in exon 9 of the PSEN1 gene, it was later shown that variations in other exons were also responsible for the disease. Objective: The current study aims to raise awareness of varAD, which occurs as a rare phenotype due to pathogenic variants in PSEN1. In addition, we aimed to evaluate the spectrum of mutations in varAD patients identified to date. Methods: Detailed family histories and clinical data were recorded. Whole exome sequencing was performed and co-segregation analysis of the family was done by Sanger sequencing. Also, a review of the molecularly confirmed patients with (varAD) from the literature was evaluated. Results: We identified a heterozygous splicing variant (c.869-1G>A) in the PSEN1 gene, in a family with two affected individuals who present with varAD. We reported the clinical and genetic findings from the affected individuals. Conclusion: We present the detailed clinical and genetic profiles of a Turkish patient with the diagnosis of varAD together with subjects from the literature. Together, we think that the clinical characteristics and the effect of the (c.869-1G>A) variant will facilitate our understanding of the PSEN1 gene in AD pathogenesis.Öğe Cyberchondria, Covid-19 phobia, and well-being: a relational study on teachers(Mattioli1885, 2022) Karakaş, Neşe; Tekin, Çiğdem; Bentli, Recep; Demir, EkremBackground: This study aims at investigating level and contributor factors of Cyberchondria, COVID-19-related Phobia, and Well-Being in a sample of teachers in Turkey. Methods: The study was conducted on teachers (n=1000) working in a province in eastern Turkey. Data for the study were collected using a form that included particitest, and Kruskal Wallis analysis of variance were used to analyze the data. Results: As participant's cyberchondria levels rose, C19P-SE scores increased (r=0.271, p<0.001), and WHO-5 scores decreased (r=-0.224, p<0.05). Corona-phobia was higher in those who used social media than in those who did not (p<0.05). Cyberchondria scale scores were higher among those who had taken medications without a physician's recommendation during the pandemic. Participants who had a disabled person or a person in need of care in their household had higher scores for distrust of the physician and C19P-SE than for the cyberchondria severity scale sub-dimension, and the WHO-5 mean scores were lower (p<0.001, P=0.016, and P=0.020, respectively).Conclusions: The study results show that increasing levels of cyberchondria trigger COVID-19 phobias in teachers during the COVID-19 pandemic and negatively affect their well-being. This descriptive study can help understand the risk group for cyberchondria, the influencing factors, and the health and economic consequences, and identify strategies for effective combating with cyberchondria.Öğe Evaluation of the efferent auditory system in COVID-19 adult patients(Taylor & Francis, 2022) Emekci, Tuğba; Dündar, Mehmet Akif; Kirazlı, Gülce; Men Kılınç, Fatma; Cengiz, Deniz Uğur; Karababa, Ercan; İnceoğlu, Feyza; Arbağ, HamdiBackground: The short- and long-term effects of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the medial olivocochlear reflex and outer hair cells in the cochlea remain largely unclear. Aims: The aim of this study was to investigate the efferent auditory system effects in adult patients with COVID-19. Materials and methods: The study included 18–50 years old 44 volunteers: 26 individuals (52 ears) with COVID-19 in the study group and 18 healthy individuals (36 ears) in the control group. Otolaryngological examination, immitancemetric evaluation, distortion product otoacoustic emission (DPOAE), contralateral acoustic stimulation with DPOAE, audiometric evaluation, and high frequency audiometric evaluation were performed in all individuals participating in the study. Results: In our study, patients with COVID-19 had significantly lower DPOAE results with or without broadband noise at only 6 kHz frequency and contralateral suppression results at all frequencies compared to healthy individuals. A statistically significant difference was found between the study and control groups according to whether the participants had a response in the high frequency audiometry at 12 and 16 kHz frequencies. Conclusions: COVID-19 affects many systems in the body. As a result of the findings obtained in the present study, it is shown that the auditory efferent system may also be affected.Öğe Determining the relationship between loneliness and depression in adolescents during the COVID-19 pandemic: A cross-sectional survey(Wiley, 2022) Kayaoğlu, Kübra; Başcıllar, MehmetPurpose: The aim of the present study is to determine the relationship between loneliness and depression felt by adolescents during the COVID-19 pandemic. Design and Methods: The study sample consisted of 423 adolescents who volunteered to participate in the study. All participants had internet access and the cognitive ability to express themselves. The participants filled out the Google Documents form that included the “Socio-demographic Data Form,” “Children's Depression Inventory,” and “Short-form UCLA Loneliness Scale” to collect data. Findings: It was determined that the depression inventory total mean score of the adolescents participating in the study was 55.15 ± 2.88 (high) and the loneliness scale total mean score was 16.43 ± 4.93 (medium). A statistically positive high correlation was found between the depression total mean scores and the loneliness total mean scores of the adolescents (p < 0.05). As the loneliness levels of the adolescents increased, their depression levels increased. Practice Implications: Adolescents were more likely to experience mental disorders such as loneliness and depression during and after the pandemic. Governments should focus on the mental health of adolescents in the management of COVID-19. Clinical services should plan and implement prevention activities, support programs, and services to replace early diagnosis and intervention.Öğe Investigation of changes in protein stability and substrate affinity of 3CL-protease of SARS-CoV-2 caused by mutations(Sociedade Brasileira de Genetica, 2022) Akbulut, Ekrem3CLpro of SARS-CoV-2 is one of the enzymes required for the replication process of the virus responsible for the COVID-19 pandemic. In this study, changes in protein stability and substrate affinity caused by mutations were investigated to stir the development of potent inhibitors. Sequence data of samples were obtained from the NCBI Virus database. Mutation analyses were performed with RDP4 and MegaX. 3CLpro tertiary models were created using Robetta. Molecular docking for peptidomimetic substrate and inhibitor ligand was done with Autodock v4.2 and Haddock v2.4. Protein stability analysis was performed using mCSM stability and DynaMut2. Twenty-four missense mutations in 3CLpro were identified in this study. Changes in the 3CLpro structure induced by the mutations Met49Thr, Leu167Ser, and Val202Ala resulted in significant levels of instability (-2.029,-2.612,-2.177 kcal.mol-1, respectively). The lowest interaction energy for substrate was-58.7 kcal.mol-1 and-62.6 kcal.mol-1 in wild-type and mutant, respectively. The lowest docking energy for ligand was-6.19 and-9.52 kcal.mol-1 for wild-type and mutant, respectively. This study reports for the first time that mutations cause increased substrate affinity of 3CLpro from SARS-CoV-2. This research provides important data for the development of potent peptidomimetic inhibitors for the treatment of COVID-19.Öğe Thermoluminescence characteristics of calcite with a Gaussian process regression model of machine learning(Wiley, 2022) Işık, EşmeThermoluminescence (TL) is defined as a luminescence phenomenon that can be detected when an insulator or semiconductor is thermally stimulated. Defective crystals store radiation until they are stimulated. Thermoluminescence is a method of monitoring the absorbed dose of dosimeters. The irradiation crystal is heated to 500°C to display the absorbed dose as a luminescent light. The TL dosimetric properties of calcite obtained from nature were investigated in this study. Machine learning was also examined using Gaussian process regression (GPR) for stimulated TL characteristics. According to the experimental output, the TL glow curve had two main peaks located at 90°C and 240°C with good dosimetric properties. In the four regression models of GPR, the data for the heating rate of 3°C s-1 have the lowest residual.Öğe Evaluation of neurological disorders that develop concurrently with COVID-19 pneumonia: a retrospective analysis(Associacao Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange / Associação Arquivos de Neuropsiquiatria Dr Oswaldo Lange, 2022) Taşçı, İrem; Balgetir, Ferhat; Müngen, Bülent; Demir, Caner Feyzi; Gönen, Murat; Delen, Leman Acun; Kurt, OsmanBackground: During the pandemic, many neurological symptoms have been evaluated as complications of COVID-19 pneumonia. Objective: To investigate the frequency and characteristics of neurological findings, and their effects on the prognosis of patients with COVID-19 pneumonia who consulted with the Neurology department. Methods: Data on 2329 patients who were hospitalized with the diagnosis of COVID-19 pneumonia in our hospital were scanned. The clinical, laboratory and radiological findings relating to treatment of 154 patients who required neurological consultation were retrospectively evaluated by reviewing the clinical notes. Results: The number of COVID-19 pneumonia patients who required neurological consultations while hospitalized in the ICU was 94 (61.0%). The most common symptom among these patients was hyperactive delirium. Mean age, ferritin levels and CRP values ??of those with delirium were higher, while the mean lymphocyte percentage were lower, than those of the patients without delirium. Epileptic seizures were observed in eight patients without an epilepsy diagnosis. Two patients were diagnosed with GBS and one patient with ICU neuropathy. The D-dimer levels of patients with acute hemorrhagic CVD and the thrombocyte levels of patients with acute ischemic CVD were found to be higher than in patients without acute ischemic CVD. Conclusion: The proportion of patients who required neurological consultations was higher in the ICUs. We observed neurological symptoms more frequently in the advanced age group. There were no significant increases in the incidence of other neurological conditions except delirium, in COVID-19 patients. We think that further studies are needed to support our data.Öğe Chemistry and engineering of brush type polymers: Perspective towards tissue engineering(Elsevier, 2022) Karaca Açarı, İdil; Sel, Evren; Özcan, İmren; Ateş, Burhan; Köytepe, Süleyman; Thakur, Vijay KumarIn tissue engineering, it is imperative to control the behaviour of cells/stem cells, such as adhesion, proliferation, propagation, motility, and differentiation for tissue regeneration. Surfaces that allow cells to behave in this way are critical as support materials in tissue engineering. Among these surfaces, brush-type polymers have an important potential for tissue engineering and biomedical applications. Brush structure and length, end groups, bonding densities, hydrophilicity, surface energy, structural flexibility, thermal stability, surface chemical reactivity, rheological and tribological properties, electron and energy transfer ability, cell binding and absorption abilities for various biological molecules of brush-type polymers were increased its importance in tissue engineering applications. In addition, thanks to these functional properties and adjustable surface properties, brush type polymers are used in different high-tech applications such as electronics, sensors, anti-fouling, catalysis, purification and energy etc. This review comprehensively highlights the use of brush-type polymers in tissue engineering applications. Considering the superior properties of brush-type polymer structures, it is believed that in the future, it will be an effective tool in structure designs containing many different biomolecules (enzymes, proteins, etc.) in the field of tissue engineering.Öğe Sol–gel synthesis of TiO2 on Co3O4-coated sporopollenin exine microcapsules (SECs) and photocatalytic performance of new semiconductor heterojunction material(Springer, 2022) Çağlar Yılmaz, Hatice; Ersoy Atalay, Funda; Kaya, Harun; Erdemoğlu, SemaIn this study, a new approach was developed to prepare mesoporous hybrid TiO2/Co3O4 coated on Juglans sporopollenin exine microcapsules (SECs). TiO2 was synthesized on Co3O4-coated SECs used as substrate, by sol–gel method. The obtained semiconductor/semiconductor hetero-junction hybrid materials were characterized with X-ray diffractometry (XRD), UV–Vis absorption spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM), particle size distribution, specific surface area, and zeta potential measurements. Photocatalytic performances of hybrid materials were tested for Reactive Black 5 dye under both UV and visible light. Equilibrium pH of the solution containing 10 mg/L Reactive Black 5 dye and 0.1% wt/v TiO2/Co3O4 was around 4.7. After irradiation in the solar box, more than 98% of the Reactive Black 5 was photocatalytically degraded within 60 min.Öğe Turkish validity and reliability study for the person-centered maternity care scale(13 haziran 2021) İnceoğlu,Feyza; Özşahin, Zeliha; Altiparmak, Sümeyye; Aksoy Derya, Yesim; Kayhan Tetik, BurcuAim: The objective was to adapt the person-centered maternity care scale (PCMCS) developed by Afulani et al. in 2017 to Turkish and to perform the validity and reliability study of this scale. Methods: The population of this methodological study consisted of 280 mothers who were referred to the postpartum service of a public hospital in eastern Turkey. Linguistic validity, context validity, and pilot practice studies regarding the PCMCS that could be used in the first nine postpartum weeks were per formed. Explanatory factor analysis and confirmatory factor analysis were performed to assess the construct validity of the form. Reliability of PCMCS was tested through the Cronbach’s ? internal consistency coeffi cient, total item correlation, and test–retest analysis. Results: The Turkish version of the PCMCS a 21-item scale with three sub-dimensions was obtained. These three sub-dimensions found as a result of explanatory factor analysis and confirmatory factor analysis supported the scale structure. Cronbach’s ? reliability coefficient scale was adequate for total and sub dimensions. Conclusion: Turkish version of PCMCS was found to be a valid and reliable instrument to be used for assessing the person-centered maternity care for women in the postpartum periodÖğe Pregnancy and its outcomes in hemodialysis patients in Turkey.(Pembegul, Irem, 2022) Hamad Dheir,; Özkan Güngör; Memnune Sena Ulu,; Ebru Gök Oğuz,; Necmi Eren,; Orçun Altunören,; Erhan Tatar,; Kadir Gökhan Atilgan,; Ibrahim Güney,; Eray Eroğlu,; Rüya Mutluay,; Ilter Bozaci,; Alper Alp,; Hakan Akdam,; Meltem Seziş Demirci,; Zeki Soypaçaci,; Özger Akarsu,; Saime Paydaş,; Zafer Ercan,; Ekrem Kara,; Cevat Topal,; Haldun Hakan Yavaş,; Nihan Tekkarişmaz,; Kenan Turgutalp; Can Hüzmeli,; Ayça Inci,; Güner Karaveli Gürsoy,; Ayşe Jini Güneş Keskin,; Bülent Huddam,; Ender Hür,; Abdulmecit Yildiz,; Garip Bekfilavioğlu,; Tuncay Şahutoğlu,; Mehmet Tuncay,; Simge Bardak,; Serkan Bakirdöğen,; Zülfükar Yilmaz,; Emrah Günay,; Onur Tunca,; Sinan Kazan,; Irem Pembegül Yiğit,; Hazen Saritaş,; Can Sevinç,; Hakan Kaptanoğullari,; Sibel Gökçay Bek,; Ilhan Kurultak,; Ali Değirmenci,; Murat Şakaci,; Ilhan Kiliç,; Zeki Aydin,; Hülya Çolak,; Erkan Dervişoğlu,; Garip Şahin,; Mehmet Deniz Ayli,; Savaş Sipahi,; Ülver DericiBackground/aim: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. Materials and methods: Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, and the information on whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. Results: In this study, we reached 9038 HD female patients’ data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 ± 7.4) years. The mean age at first gestation was 30.8 ± 6.5 years. The average birth week was 32 (28 –36) weeks. A total of 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients’ increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). Conclusion: For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that; increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates.Öğe Socio-Economic, Demographic and Health Determinants of the COVID-19 Outbreak(MDPI, 2022) Özyılmaz, Ayfer; Bayraktar, Yüksel; Toprak, Metin; Işık, Esme; Güloğlu, Tuncay; Aydın, Serdar; Olgun, Mehmet Fırat; Younis, MustafaObjective: In this study, the effects of social and health indicators affecting the number of cases and deaths of the COVID-19 pandemic were examined. For the determinants of the number of cases and deaths, four models consisting of social and health indicators were created. Methods: In this quantitative research, 93 countries in the model were used to obtain determinants of the confirmed cases and determinants of the COVID-19 fatalities. Results: The results obtained from Model I, in which the number of cases was examined with social indicators, showed that the number of tourists, the population between the ages of 15 and 64, and institutionalization had a positive effect on the number of cases. The results obtained from the health indicators of the number of cases show that cigarette consumption affects the number of cases positively in the 50th quantile, the death rate under the age of five affects the number of cases negatively in all quantiles, and vaccination positively affects the number of cases in 25th and 75th quantile values. Findings from social indicators of the number of COVID-19 deaths show that life expectancy negatively affects the number of deaths in the 25th and 50th quantiles. The population over the age of 65 and CO2 positively affect the number of deaths at the 25th, 50th, and 75th quantiles. There is a non-linear relationship between the number of cases and the number of deaths at the 50th and 75th quantile values. An increase in the number of cases increases the number of deaths to the turning point; after the turning point, an increase in the number of cases decreases the death rate. Herd immunity has an important role in obtaining this finding. As a health indicator, it was seen that the number of cases positively affected the number of deaths in the 50th and 75th quantile values and the vaccination rate in the 25th and 75th quantile values. Diabetes affects the number of deaths positively in the 75th quantile. Conclusion: The population aged 15–64 has a strong impact on COVID-19 cases, but in COVID-19 deaths, life expectancy is a strong variable. On the other hand, it has been found that vaccination and the number of cases interaction term has an effect on the mortality rate. The number of cases has a non-linear effect on the number of deaths.
