Resistin predicts ischemia in myocardial perfusion scintigraphy

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dc.authoridYilmaz, Ayse Esra/0000-0002-9671-749X;
dc.contributor.authorYildirim, Mustafa
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorAsik, Muhammet
dc.contributor.authorUcgun, Taner
dc.contributor.authorYilmaz, Ayse
dc.contributor.authorIlce, Huri Tilla
dc.contributor.authorAslantas, Yusuf
dc.date.accessioned2025-10-24T18:09:50Z
dc.date.available2025-10-24T18:09:50Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single-photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed as ischemic or nonischemic. Resistin levels were presented as medians (25th-75th percentiles) and were compared using the Mann-Whitney U test. Results: Plasma resistin levels were higher in the ischemic group (n = 47) than in the nonischemic group (n = 67) [9.04 mu mol/L (6.27-11.8 mu mol/L) vs. 3.56 mu mol/L (0.39-7.93 mu mol/L), respectively; P < 0.001). We showed that plasma resistin levels (OR = 1.26, 95% CI: 1.13-1.41; P < 0.001) and METs (OR = 0.82, 95% CI: 0.70-0.92; P = 0.021) were independent predictors of ischemia. No linear correlation was found between plasma resistin levels and GATED SPECT or stress test parameters. Conclusion: Increased baseline resistin levels are independently related to presence of ischemia but are not related to the extent or severity of ischemia, or other functional parameters such as poststress ejection fraction, end systolic, and end diastolic volumes.
dc.identifier.doi10.3906/sag-1302-146
dc.identifier.endpage500
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3
dc.identifier.pmid25558655
dc.identifier.scopus2-s2.0-84897878900
dc.identifier.scopusqualityQ1
dc.identifier.startpage496
dc.identifier.trdizinid213104
dc.identifier.urihttps://doi.org/10.3906/sag-1302-146
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/213104
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3858
dc.identifier.volume44
dc.identifier.wosWOS:000334063700024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectResistin; myocardial perfusion scintigraphy; ischemia
dc.titleResistin predicts ischemia in myocardial perfusion scintigraphy
dc.typeArticle

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