Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1

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dc.authoridacar, muradiye/0000-0003-4357-5229;
dc.contributor.authorKaya, Gulhan
dc.contributor.authorGunduz, Esra
dc.contributor.authorAcar, Muradiye
dc.contributor.authorHatipoglu, Omer Faruk
dc.contributor.authorAcar, Burcu
dc.contributor.authorIlhan, Atilla
dc.contributor.authorGunduz, Mehmet
dc.date.accessioned2025-10-24T18:09:56Z
dc.date.available2025-10-24T18:09:56Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: Alzheimer disease (AD) is triggered by interactions of multiple genetic and environmental factors. The APOE gene E4 allele is the best-known risk factor for AD, yet it represents a small ratio of genetic factors. According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene. We aimed to identify a novel biomarker indicating susceptibility to AD by investigating APOE alleles and BIN1 gene polymorphisms in a Turkish population. Materials and methods: Fifty-three AD patients and 56 controls were included to examine polymorphism and allele frequency of the APOE and BIN1 genes. Genomic DNAs were isolated from whole blood by SDS/proteinase K treatment, phenol-chloroform extraction, and ethanol precipitation. RFLP was done for identification of polymorphisms in the APOE gene and allele-specific PCR was used for the BIN1 gene. Results: Frequency of the APOE E4 allele was higher in the AD patient group, while the frequency of the E2 allele was higher in controls. The E4/E4 genotype was detected in the AD patient group, while this genotype was not observed in the controls. The frequencies of BIN1 alleles were similar in both groups. Conclusion: There was a strong association between AD and the APOE E4 allele, while no such relation was observed with BIN1 gene polymorphism.
dc.description.sponsorshipScientific Research Fund of Turgut Ozal University [P53011102_G]; Scientific Research Fund of Fatih University [P53011102_G]
dc.description.sponsorshipThis work was supported by the Scientific Research Fund of Turgut Ozal and Fatih Universities under project number P53011102_G.
dc.identifier.doi10.3906/sag-1405-96
dc.identifier.endpage1072
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.pmid26738348
dc.identifier.scopus2-s2.0-84943224021
dc.identifier.scopusqualityQ1
dc.identifier.startpage1058
dc.identifier.trdizinid180097
dc.identifier.urihttps://doi.org/10.3906/sag-1405-96
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/180097
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3877
dc.identifier.volume45
dc.identifier.wosWOS:000362526300013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAlzheimer disease; APOE; BIN1; polymorphism; biomarker; RFLP
dc.titlePotential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1
dc.typeArticle

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