Application of Dempster-Schafer Method in Family-Based Association Studies

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dc.authoridGoktas, Unal/0000-0002-1937-6302|Göktaş, Ünal/0000-0003-1458-0387
dc.contributor.authorRajabli, Farid
dc.contributor.authorGoktas, Unal
dc.contributor.authorInan, Gul
dc.date.accessioned2025-10-24T18:09:22Z
dc.date.available2025-10-24T18:09:22Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has a promising overall performance, in identifying single-nucleotide polymorphisms in the correct association class, as it has 90 percent accuracy even with 60 trios.
dc.identifier.doi10.1109/TCBB.2013.85
dc.identifier.endpage1075
dc.identifier.issn1545-5963
dc.identifier.issn1557-9964
dc.identifier.issue4
dc.identifier.pmid24334398
dc.identifier.scopus2-s2.0-84890445305
dc.identifier.scopusqualityQ1
dc.identifier.startpage1071
dc.identifier.urihttps://doi.org/10.1109/TCBB.2013.85
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3595
dc.identifier.volume10
dc.identifier.wosWOS:000328640700022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIeee Computer Soc
dc.relation.ispartofIeee-Acm Transactions On Computational Biology And Bioinformatics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAlgorithm design and analysis; biology and genetics; knowledge and data engineering tools and techniques; probabilistic algorithms
dc.titleApplication of Dempster-Schafer Method in Family-Based Association Studies
dc.typeArticle

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