Application of Dempster-Schafer Method in Family-Based Association Studies
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ieee Computer Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In experiments designed for family-based association studies, methods such as transmission disequilibrium test require large number of trios to identify single-nucleotide polymorphisms associated with the disease. However, unavailability of a large number of trios is the Achilles' heel of many complex diseases, especially for late-onset diseases. In this paper, we propose a novel approach to this problem by means of the Dempster-Shafer method. The simulation studies show that the Dempster-Shafer method has a promising overall performance, in identifying single-nucleotide polymorphisms in the correct association class, as it has 90 percent accuracy even with 60 trios.
Açıklama
Anahtar Kelimeler
Algorithm design and analysis; biology and genetics; knowledge and data engineering tools and techniques; probabilistic algorithms
Kaynak
Ieee-Acm Transactions On Computational Biology And Bioinformatics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
10
Sayı
4
