The prevalence of infectious agents in patients with systemic sclerosis

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dc.contributor.authorBilgin, Huseyin
dc.contributor.authorKocabas, Hilal
dc.contributor.authorKesli, Recep
dc.date.accessioned2025-10-24T18:09:53Z
dc.date.available2025-10-24T18:09:53Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular injury, excessive extracellular matrix deposition, and fibrosis in the skin and internal organs. Bacterial and viral infectious agents have been suspected to be contributing factors in the development and progression of the pathologic features of SSc. Materials and methods: In this study, 30 SSc patients who were admitted to the rheumatology unit of the Konya Training and Research Hospital and 30 healthy controls were included. The presence of 9 different antibodies (IgM and IgG) against Helicobacter pylori, cytomegalovirus (CMV), Epstein-Barr virus (EBV), and parvovirus B19 were investigated in sera samples obtained from the 60 participants using an enzyme-linked immunosorbent assay method. The characteristics of current and past infections with H. pylori, CMV, EBV, and parvovirus B19 were evaluated by determining the seropositivity of the tested bacterial and viral agents. Results: The prevalences of H. pylori, CMV, EBV, and parvovirus B19 were determined to be higher in patients with SSc than in the control group. Conclusion: SSc is associated with a higher rate of certain infections, which deserves further investigation in order to assess the role of infections in disease etiology/pathogenesis.
dc.identifier.doi10.3906/sag-1404-150
dc.identifier.endpage1197
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid26775370
dc.identifier.scopus2-s2.0-84947423422
dc.identifier.scopusqualityQ1
dc.identifier.startpage1192
dc.identifier.trdizinid186442
dc.identifier.urihttps://doi.org/10.3906/sag-1404-150
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/186442
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3873
dc.identifier.volume45
dc.identifier.wosWOS:000365510300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectSystemic sclerosis; infection; etiology
dc.titleThe prevalence of infectious agents in patients with systemic sclerosis
dc.typeArticle

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