Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats

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dc.authoridOzsoy, Seyma/0000-0003-1783-3618|BILGINOGLU, AYCA/0000-0002-1657-2607
dc.contributor.authorBilginoglu, Ayca
dc.contributor.authorAydin, Duygu
dc.contributor.authorOzsoy, Seyma
dc.contributor.authorAygun, Hatice
dc.date.accessioned2025-10-24T18:10:11Z
dc.date.available2025-10-24T18:10:11Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Adriamycin is one of the most widely used anticancer drugs. The major limiting factor of using this drug is the development of cardiotoxicity. However, melatonin (N-acetyl-5- methoxytryptamine) is a ubiquitous molecule as a good antioxidant that may protect the heart. We investigated whether or not pretreatment with melatonin can attenuate adriamycin-induced cardiotoxicity. Study design: All procedures and experiments were approved by the Animal Ethics Committee of Gazi Osman Pasa University (2012-HADYEK-022). Adult male Wistar-Albino rats were randomly divided into four groups, namely control (CON, n=7), melatonin (MEL, n=7), adriamycin (ADR, n=7), and adriamycin+melatonin (ADR+MEL, n=7) groups. Cardiotoxicity in rats was induced by adriamycin injection (cumulative dose: 18 mg/kg, intraperitoneal [i.p.]) at an interval of 24 hours (h) on the 5th, 6th and 7th days. Rats receiving melatonin treatment in the adriamycin group received melatonin (10 mg/kg/day, i.p.) for 7 days and were injected with adriamycin (18 mg/kg, i. p.) on 5th, 6th and 7th days. On the 8th day, gravimetric, electrocardiography (ECG) and biochemical parameters were assessed. Results: Adriamycin induction caused changes in the ECG pattern, including ST-segment elevation and decreased R-amplitude, increase in the serum levels of cardiac injury markers (creatine kinase [CK], CK-MB, aspartate transaminase, and lactate dehydrogenase), decrease in the antioxidant enzymes activity (superoxide dismutase, glutathione peroxidase), elevated lipid peroxidation (malondialdehyde), and altered lipid profile in the serum. Melatonin treatment prevented all the parameters of adriamycin-induced cardiotoxicity in rats. Conclusion: Melatonin has a protective effect on the heart against adriamycin-induced cardiotoxicity in rats.
dc.identifier.doi10.5543/tkda.2014.36089
dc.identifier.endpage273
dc.identifier.issn1016-5169
dc.identifier.issue3
dc.identifier.pmid24769819
dc.identifier.scopus2-s2.0-84900455886
dc.identifier.scopusqualityQ3
dc.identifier.startpage265
dc.identifier.trdizinid162229
dc.identifier.urihttps://doi.org/10.5543/tkda.2014.36089
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/162229
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4026
dc.identifier.volume42
dc.identifier.wosWOS:000421940400006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAdriamycin; antioxidants; cardiovascular diseases/prevention & control; coronary disease; disease models; animal; melatonin; rats; Wistar
dc.titleProtective effect of melatonin on adriamycin-induced cardiotoxicity in rats
dc.typeArticle

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