Can copeptin predict the severity of coronavirus disease 2019 infection?

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dc.authorid0000-0002-8807-5853en_US
dc.contributor.authorİn, Erdal
dc.contributor.authorKuluöztürk, Mutlu
dc.contributor.authorTelo, Selda
dc.contributor.authorToraman, Zülal Aşçı
dc.contributor.authorKarabulut, Ercan
dc.date.accessioned2021-12-04T19:00:30Z
dc.date.available2021-12-04T19:00:30Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionOriginal Articleen_US
dc.description.abstractObjetive: Coronavirus disease 2019 (COVID-19) has quickly turned into a health problem globally. Early and effective predictors of disease severity are needed to improve the management of the patients affected with COVID-19. Copeptin, a 39-amino acid glycopeptide, is known as a C-terminal unit of the precursor pre-provasopressin (pre-proAVP). Activation of AVP system stimulates copeptin secretion in equimolar amounts with AVP. This study aimed to determine serum copeptin levels in the patients with COVID-19 and to examine the relationship between serum copeptin levels and the severity of the disease. Methods: The study included 90 patients with COVID-19. The patients with COVID-19 were divided into two groups according to disease severity as mild/moderate disease (n=35) and severe disease (n=55). All basic demographic and clinical data of the patients were recorded and blood samples were collected. Results: Copeptin levels were significantly higher in the patients with severe COVID-19 compared with the patients with mild/moderate COVID-19 (p<0.001). Copeptin levels were correlated with ferritin and fibrinogen levels positively (r=0.32, p=0.002 and r=0.25, p=0.019, respectively), and correlated with oxygen saturation negatively (r=-0.37, p<0.001). In the multivariate logistic regression analysis, it was revealed that copeptin (OR: 2.647, 95%CI 1.272-5.510; p=0.009) was an independent predictor of severe COVID-19 disease. A cutoff value of 7.84 ng/mL for copeptin predicted severe COVID-19 with a sensitivity of 78% and a specificity of 80% (AUC: 0.869, 95%CI 0.797-0.940; p<0.001). Conclusion: Copeptin could be used as a favorable prognostic biomarker while determining the disease severity in COVID-19.en_US
dc.identifier.citationİn, E., Kuluöztürk, M., Telo, S., Toraman, Z. A., & Karabulut, E. (2021). Can copeptin predict the severity of coronavirus disease 2019 infection?. Revista da Associação Médica Brasileira, 67(8), 1137-1142.en_US
dc.identifier.doi10.1590/1806-9282.20210525
dc.identifier.endpage1142en_US
dc.identifier.issn0104-4230en_US
dc.identifier.issn1806-9282en_US
dc.identifier.issue8en_US
dc.identifier.pmid34669859
dc.identifier.scopus2-s2.0-85118249097en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1137en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20210525
dc.identifier.urihttps://hdl.handle.net/20.500.12899/512
dc.identifier.volume67en_US
dc.identifier.wosWOS:000708990100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİn, Erdal
dc.language.isoenen_US
dc.publisherAssociação Médica Brasileiraen_US
dc.relation.ispartofRevista da Associação Médica Brasileiraen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectMild/Moderate COVID-19en_US
dc.subjectSevere COVID-19en_US
dc.subjectCopeptinen_US
dc.subjectBiomarkersen_US
dc.titleCan copeptin predict the severity of coronavirus disease 2019 infection?en_US
dc.typeArticleen_US

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