The increase of mean platelet volume in patients with Alzheimer disease

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dc.authoridParlak, Digdem/0000-0001-9430-888X|KOC, EMINE RABIA/0000-0002-0264-7284;
dc.contributor.authorKoc, Emine Rabia
dc.contributor.authorUzar, Ertugrul
dc.contributor.authorCirak, Yasemin
dc.contributor.authorParlak Demir, Yasemin
dc.contributor.authorIlhan, Atilla
dc.date.accessioned2025-10-24T18:09:50Z
dc.date.available2025-10-24T18:09:50Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE >= 18) and moderate (MMSE < 18), and their MPV levels were compared. Results: MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values. Conclusion: Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.
dc.identifier.doi10.3906/sag-1212-5
dc.identifier.endpage1066
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid25552162
dc.identifier.scopus2-s2.0-84908067164
dc.identifier.scopusqualityQ1
dc.identifier.startpage1060
dc.identifier.trdizinid213224
dc.identifier.urihttps://doi.org/10.3906/sag-1212-5
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/213224
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3854
dc.identifier.volume44
dc.identifier.wosWOS:000344155900023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAlzheimer disease; dementia; cognitive decline; mean platelet volume; platelet activation; vascular risk factors
dc.titleThe increase of mean platelet volume in patients with Alzheimer disease
dc.typeArticle

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