The role of endobronchial ultrasound-guided transbronchial needle aspiration in the differential diagnosis of isolated mediastinal and/or hilar lymphadenopathy

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dc.authorid0000-0002-8807-5853en_US
dc.contributor.authorTemiz, Dilek
dc.contributor.authorİn, Erdal
dc.contributor.authorKuluöztürk, Mutlu
dc.contributor.authorKırkıl, Gamze
dc.contributor.authorArtaş, Gökhan
dc.contributor.authorTurgut, Teyfik
dc.contributor.authorDeveci, Figen
dc.date.accessioned2021-11-25T06:54:45Z
dc.date.available2021-11-25T06:54:45Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Isolated mediastinal and/or hilar lymphadenopathy (IMHL) has become an increasingly common finding as a result of the increased use of thoracic imaging modalities. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is accepted as the first step diagnostic method in the differential diagnosis of IMHL. Objective: To determine the diagnostic yield of the procedure and to analyze clinical and sonographic findings that can be used to differentiate the etiology of lymph node pathologies. Methods: Patients who underwent EBUS-TBNA procedure between March 2017 and March 2020 were included in this retrospective study. Demographic data, symptoms, comorbid diseases, and EBUS findings were obtained from the records of the patients. Results: EBUS-TBNA provided a diagnosis in 88 patients out of 120 patients (granulomatous diseases n = 54, malignant diseases n = 21, and anthracotic lymph nodes n = 13), and 32 patients had a negative EBUS-TBNA. 22/32 negative EBUS-TBNA samples were true negatives (reactive lymphadenopathy). The sensitivity of the procedure was 89.8% while negative predict value was 68.7%, diagnostic yield of 91.6%. Patients with reactive lymph nodes had significantly more comorbidities (77.3%–19.4%, p <.001) and a lower number of lymph node stations (1.6 ± 0.8–2.7 ± 0.9, p <.001). Patients with anthracotic lymph nodes were older and mostly consisted of females (11/13, p <.001). Conclusion: EBUS-TBNA has high-diagnostic efficiency in the differential diagnosis of IMHL. The number and size of lymph node stations can provide useful information for differential diagnosis. Clinical follow-up can be a more beneficial approach in patients with reactive and anthracotic lymph nodes before invasive sampling.en_US
dc.identifier.citationTemiz, D., İn, E., Kuluöztürk, M., Kırkıl, G., Artaş, G., Turgut, T., & Deveci, F. (2021). The role of endobronchial ultrasound‐guided transbronchial needle aspiration in the differential diagnosis of isolated mediastinal and/or hilar lymphadenopathy. Diagnostic Cytopathology.en_US
dc.identifier.doi10.1002/dc.24807
dc.identifier.endpage1021en_US
dc.identifier.issn8755-1039en_US
dc.identifier.issn1097-0339en_US
dc.identifier.issue9en_US
dc.identifier.pmid34078002
dc.identifier.scopus2-s2.0-85107015661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1012en_US
dc.identifier.urihttps://doi.org/10.1002/dc.24807
dc.identifier.urihttps://hdl.handle.net/20.500.12899/489
dc.identifier.volume49en_US
dc.identifier.wosWOS:000657062100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorİn, Erdal
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDiagnostic Cytopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReactive lymph nodeen_US
dc.subjectEndobronchial ultrasonographyen_US
dc.subjectMediastinal lymphadenopathyen_US
dc.subjectReactive lymph nodeen_US
dc.subjectTransbronchial needle aspirationen_US
dc.titleThe role of endobronchial ultrasound-guided transbronchial needle aspiration in the differential diagnosis of isolated mediastinal and/or hilar lymphadenopathyen_US
dc.typeArticleen_US

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