Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects

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dc.contributor.authorArmutcu, Ferah
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorUstunsoy, Seyfettin
dc.contributor.authorTuran, Fatime Filiz
dc.date.accessioned2025-10-24T18:09:47Z
dc.date.available2025-10-24T18:09:47Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCaffeic acid phenethyl ester (CAPE), a naturally occurring compound isolated from propolis extract, has been reported to have a number of biological and pharmacological properties, exerting antioxidant, anti-inflammatory, anticarcinogenic, antibacterial and immunomodulatory effects. Recent in vivo and in vitro study findings have provided novel insights into the molecular mechanisms involved in the anti-inflammatory and immunomodulatory activities of this natural compound. CAPE has been reported to have anti-inflammatory properties involving the inhibition of certain enzyme activities, such as xanthine oxidase, cyclooxygenase and nuclear factor-kappa B (NF-kappa B) activation. Since inflammation. and immune mechanisms play a crucial role in the onset of several inflammatory diseases, the inhibition of NF-kappa B represents a rationale for the development of novel and safe anti-inflammatory agents. The primary goal of the present review is to highlight the anti-inflammatory and immunomodulatory activities of CAPE, and critically evaluate its potential therapeutic effects.
dc.identifier.doi10.3892/etm.2015.2346
dc.identifier.endpage1588
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue5
dc.identifier.pmid26136862
dc.identifier.scopus2-s2.0-84925070736
dc.identifier.scopusqualityN/A
dc.identifier.startpage1582
dc.identifier.urihttps://doi.org/10.3892/etm.2015.2346
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3829
dc.identifier.volume9
dc.identifier.wosWOS:000353849700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofExperimental And Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectcaffeic acid phenethyl ester; anti-inflammatory activity; immunomodulatory effect
dc.titleTherapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects
dc.title.alternativeTherapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects (Review)
dc.typeReview Article

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