Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Spandidos Publ Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Caffeic acid phenethyl ester (CAPE), a naturally occurring compound isolated from propolis extract, has been reported to have a number of biological and pharmacological properties, exerting antioxidant, anti-inflammatory, anticarcinogenic, antibacterial and immunomodulatory effects. Recent in vivo and in vitro study findings have provided novel insights into the molecular mechanisms involved in the anti-inflammatory and immunomodulatory activities of this natural compound. CAPE has been reported to have anti-inflammatory properties involving the inhibition of certain enzyme activities, such as xanthine oxidase, cyclooxygenase and nuclear factor-kappa B (NF-kappa B) activation. Since inflammation. and immune mechanisms play a crucial role in the onset of several inflammatory diseases, the inhibition of NF-kappa B represents a rationale for the development of novel and safe anti-inflammatory agents. The primary goal of the present review is to highlight the anti-inflammatory and immunomodulatory activities of CAPE, and critically evaluate its potential therapeutic effects.
Açıklama
Anahtar Kelimeler
caffeic acid phenethyl ester; anti-inflammatory activity; immunomodulatory effect
Kaynak
Experimental And Therapeutic Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
9
Sayı
5
