Application of kappa statistics in sequential tests for family-based design

Basit Öğe Kaydı
dc.contributor.authorRajabli, Farid
dc.date.accessioned2025-10-24T18:09:48Z
dc.date.available2025-10-24T18:09:48Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractFamily-based designs are commonly used in genetic association studies to locate markers associated with diseases. It is a challenging task to collect a large enough sample size, perform a statistical test, and obtain the desired statistical power. The sequential probability ratio test (SPRT) was introduced to overcome the limited sample size problem. However, the drawback of SPRT is that, for the sake of accuracy, the test leaves many markers in a gray zone meaning no decision. In this article, we propose a novel approach: a sequential probability ratio test 'plus' (SPRT+) to reduce the number of these gray zone markers. Using simulated data, the results of SPRT+ are compared with the results of SPRT. SPRT+ shows a promising overall performance in identifying highly and moderately associated markers in the correct association region without a loss of accuracy.
dc.identifier.doi10.3906/elk-1401-283
dc.identifier.endpage1991
dc.identifier.issn1300-0632
dc.identifier.issn1303-6203
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84963800328
dc.identifier.scopusqualityQ2
dc.identifier.startpage1984
dc.identifier.trdizinid245366
dc.identifier.urihttps://doi.org/10.3906/elk-1401-283
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/245366
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3845
dc.identifier.volume24
dc.identifier.wosWOS:000374121500090
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Electrical Engineering And Computer Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMarkers; sequential probability ratio test; simulation study; family-based association study; kappa statistics
dc.titleApplication of kappa statistics in sequential tests for family-based design
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu