Application of kappa statistics in sequential tests for family-based design
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technological Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Family-based designs are commonly used in genetic association studies to locate markers associated with diseases. It is a challenging task to collect a large enough sample size, perform a statistical test, and obtain the desired statistical power. The sequential probability ratio test (SPRT) was introduced to overcome the limited sample size problem. However, the drawback of SPRT is that, for the sake of accuracy, the test leaves many markers in a gray zone meaning no decision. In this article, we propose a novel approach: a sequential probability ratio test 'plus' (SPRT+) to reduce the number of these gray zone markers. Using simulated data, the results of SPRT+ are compared with the results of SPRT. SPRT+ shows a promising overall performance in identifying highly and moderately associated markers in the correct association region without a loss of accuracy.
Açıklama
Anahtar Kelimeler
Markers; sequential probability ratio test; simulation study; family-based association study; kappa statistics
Kaynak
Turkish Journal Of Electrical Engineering And Computer Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
24
Sayı
3
