Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses

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dc.authorid0000-0002-2966-9627en_US
dc.contributor.authorYılmaz, İsmet
dc.contributor.authorMaraş, Zeynep
dc.contributor.authorUğur, Yılmaz
dc.contributor.authorÖzgür, Mustafa Erkan
dc.contributor.authorDurmaz, Murat
dc.contributor.authorUlusoy, Halil İbrahim
dc.contributor.authorErdoğan, Selim
dc.date.accessioned2021-09-05T16:47:25Z
dc.date.available2021-09-05T16:47:25Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Doğanşehir Vahap Küçük Meslek Yüksekokulu, Su Ürünleri Bölümüen_US
dc.description.abstractMetamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methylamino antipyrine (MAA), an active primary metabolite of MT. The present study aims to determine the pharmacokinetic (PK) profiles of MT metabolites after intravenous (IV) and intramuscular (IM) administration into sex of Arabian horses (Equus ferus caballus) using a cross-over study design. The plasma samples were extracted by solid-phase extraction (SPE) method, and plasma concentrations of MT metabolites were analyzed by high-performance liquid chromatography (HPLC). After administrations of MT, plasma concentrations of methylamino antipyrine (MAA), amino antipyrone (AA), and acetylamino antipyrone (AAA) were determined within range of 15 min-12 h. Plasma concentrations of AA and AAA were lower than the plasma concentrations of major metabolite MAA at each sampling point. The PK parameters were statistically evaluated for MT's metabolites between male and female horses and also between IM and IV administrations of PK parameters such as Cmax , tmax , t1/2?z , AUC0-t , AUC0-? , ?z, Cl and Vss (p < .05). The AUCIM /AUCIV ratio in female and male horses for MAA was 1.19 and 1.13, respectively. The AUCIM /AUCIV ratio for AA was lower than those found for MAA. AUCIM /AUCIV ratio was statistically significantly different between male and female horses for AA (p < .05). According to these results, some PK parameters such as Cmax, AUC, and MRT, MAA and AA concentrations have shown statistically significant differences by MT administrations.en_US
dc.identifier.citationYılmaz, İ., Maraş, Z., Uğur, Y., Erkan Özgür, M., Durmaz, M., İbrahim Ulusoy, H., & Erdoğan, S. (2021). Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses. Journal of Veterinary Pharmacology and Therapeutics.en_US
dc.identifier.doi10.1111/jvp.13003
dc.identifier.endpage10en_US
dc.identifier.issn0140-7783en_US
dc.identifier.issn1365-2885en_US
dc.identifier.pmid34431528
dc.identifier.scopus2-s2.0-85113349552en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.13003
dc.identifier.urihttps://hdl.handle.net/20.500.12899/387
dc.identifier.wosWOS:000688081600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzgür, Mustafa Erkan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArabian horsesen_US
dc.subjectHPLCen_US
dc.subjectMetamizoleen_US
dc.subjectPharmacokineticsen_US
dc.subjectSolid-phase extractionen_US
dc.titlePharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horsesen_US
dc.typeArticleen_US

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