In Vivo and In Vitro Antneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives

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dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorOzturk, Gulfer
dc.contributor.authorGinis, Zeynep
dc.contributor.authorArmutcu, Ferah
dc.contributor.authorYigitoglu, M. Ramazan
dc.contributor.authorAkyol, Omer
dc.date.accessioned2025-10-24T18:09:13Z
dc.date.available2025-10-24T18:09:13Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-B at M concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.
dc.description.sponsorshipFatih University BAP Project section for the master thesis [53011002]
dc.description.sponsorshipAuthors would like to thank Assoc. Prof. Dr. Gonul Erden for her great assistance to write down this article. This study was partly supported by Fatih University BAP Project section for the master thesis (S. Akyol, postgraduate student, 53011002).
dc.identifier.doi10.1080/01635581.2013.776693
dc.identifier.endpage526
dc.identifier.issn0163-5581
dc.identifier.issue4
dc.identifier.pmid23659443
dc.identifier.scopus2-s2.0-84877970486
dc.identifier.scopusqualityQ1
dc.identifier.startpage515
dc.identifier.urihttps://doi.org/10.1080/01635581.2013.776693
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3536
dc.identifier.volume65
dc.identifier.wosWOS:000318973200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofNutrition And Cancer-An International Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectFactor-Kappa-B; Human Breast-Cancer; C6 Glioma-Cells; Leukemia Hl-60 Cells; Aberrant Crypt Foci; Intercellular Communication; Polyphenolic Compounds; Oxidative Stress; Epithelial-Cells; Rat Colon
dc.titleIn Vivo and In Vitro Antneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives
dc.title.alternativeIn vivo and in vitro antineoplastic actions of Caffeic acid phenethyl ester (CAPE): Therapeutic perspectives
dc.typeArticle

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