Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

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dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X;
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorSimavli, Serap Aynur
dc.contributor.authorEser, Ayla
dc.contributor.authorInegol Gumus, Ilknur
dc.contributor.authorYuksel, Selcen
dc.contributor.authorIltemir Duvan, Zehra Candan
dc.contributor.authorKafali, Hasan
dc.date.accessioned2025-10-24T18:09:52Z
dc.date.available2025-10-24T18:09:52Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.
dc.identifier.doi10.3906/sag-1311-88
dc.identifier.endpage984
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid25552150
dc.identifier.scopus2-s2.0-84908059063
dc.identifier.scopusqualityQ1
dc.identifier.startpage980
dc.identifier.trdizinid213209
dc.identifier.urihttps://doi.org/10.3906/sag-1311-88
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/213209
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3871
dc.identifier.volume44
dc.identifier.wosWOS:000344155900011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMean platelet volume; menopause; cardiovascular risk; hormone replacement therapy; lipid profile
dc.titleEffects of oral hormone replacement therapy on mean platelet volume in postmenopausal women
dc.typeArticle

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