Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy

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dc.authoridYilmaz, Ayse Esra/0000-0002-9671-749X;
dc.contributor.authorErkan, Melih Engin
dc.contributor.authorAsik, Muhammet
dc.contributor.authorUcgun, Taner
dc.contributor.authorYildiz, Nilgun
dc.contributor.authorYilmaz, Ayse
dc.contributor.authorAslantas, Yusuf
dc.contributor.authorBulur, Serkan
dc.date.accessioned2025-10-24T18:09:53Z
dc.date.available2025-10-24T18:09:53Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms. We hypothesized that plasma ADMA levels would be increased in the presence of reversible ischemia as measured by GATED single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy (MPS). Materials and methods: Fasting i.v. blood samples were drawn before testing. All patients underwent 99mTc-sestamibi GATED SPECT MPS with a one-day stress-rest protocol; the images were visually analyzed. Post-stress GATED parameters, including ejection fraction, end systolic and end diastolic volumes, and automatic stress defect scores, were recorded. Results: The plasma ADMA levels were higher in the ischemic group than in the non-ischemic group (0.46 +/- 0.19 vs. 0.40 +/- 0.15; P = 0.016). Plasma ADMA levels (odds ratio [OR] = 13.5; 95% confidence interval [CI] = 1.7-109.01; P = 0.015) and sex (OR = 2.49, 95% CI = 1.18-5.26; P = 0.017) were independent predictors of ischemia. There was no linear correlation between plasma ADMA levels and both the GATED SPECT and stress test parameters. Conclusion: Our data support the hypothesis that increased baseline ADMA levels are independently related with the presence of reversible ischemia.
dc.identifier.doi10.3906/sag-1404-32
dc.identifier.endpage958
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid26422873
dc.identifier.scopus2-s2.0-84933036044
dc.identifier.scopusqualityQ1
dc.identifier.startpage954
dc.identifier.trdizinid180837
dc.identifier.urihttps://doi.org/10.3906/sag-1404-32
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/180837
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3874
dc.identifier.volume45
dc.identifier.wosWOS:000359064200034
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAsymmetric dimethylarginine; single photon emission computed tomography; ischemia
dc.titleAsymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy
dc.typeArticle

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