Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases

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dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorUgurcu, Veli
dc.contributor.authorBalci, Mehmet
dc.contributor.authorGurel, Ayse
dc.contributor.authorErden, Gonul
dc.contributor.authorCakmak, Ozlem
dc.contributor.authorAkyol, Omer
dc.date.accessioned2025-10-24T18:09:16Z
dc.date.available2025-10-24T18:09:16Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAs an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.
dc.identifier.doi10.1089/jop.2014.0046
dc.identifier.endpage708
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue9
dc.identifier.pmid25100535
dc.identifier.scopus2-s2.0-84932120375
dc.identifier.scopusqualityQ1
dc.identifier.startpage700
dc.identifier.urihttps://doi.org/10.1089/jop.2014.0046
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3557
dc.identifier.volume30
dc.identifier.wosWOS:000344386300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectStaphylococcus-Epidermidis Endophthalmitis; Endotoxin-Induced Uveitis; Endothelial Growth-Factor; Pigment Epithelial-Cells; Induced Diabetic-Rats; Ischemia-Reperfusion; Oxidative Stress; Mouse Skin; Proliferative Vitreoretinopathy; Ischemia/Reperfusion Injury
dc.titleCaffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases
dc.typeReview Article

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