Prohepcidin in maternal circulation: is it related to spontaneous preterm labor?

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dc.authoridBicer, Cemile/0000-0001-7937-4475;
dc.contributor.authorOnaran, Yuksel
dc.contributor.authorAktepe Keskin, Esra
dc.contributor.authorIltemir Duvan, Zehra Candan
dc.contributor.authorSimavli, Serap Aynur
dc.contributor.authorKoca, Cemile
dc.contributor.authorKafali, Hasan
dc.contributor.authorTurhan, Nilgun
dc.date.accessioned2025-10-24T18:09:51Z
dc.date.available2025-10-24T18:09:51Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: To investigate whether spontaneous preterm labor (PTL) with intact membranes is associated with changes in maternal serum prohepcidin concentrations. Materials and methods: The study consisted of patients with spontaneous PTL with intact membranes (n = 25), a control group of healthy pregnant women between the 24th and 37th gestational weeks (n = 22), and uncomplicated term pregnancies in spontaneous labor (n = 19). Blood samples were collected from patients at the time of clinical diagnosis. Levels of prohepcidin, hemoglobin, serum ferritin, serum iron, unsaturated iron binding capacity, total iron binding capacity, transferrin and transferrin saturation, C reactive protein, and interleukin-6 were measured. Results: Patients with spontaneous PTL had significantly lower maternal serum prohepcidin concentrations than term delivery and control subjects. Conclusion: Maternal serum prohepcidin concentration is lower in patients with spontaneous PTL compared to term delivery and control subjects. This suggests that measuring maternal serum prohepcidin concentrations in PTL may be a feasible method for understanding etiologic causes of spontaneous preterm delivery, but, before suggesting this as a course of action, low levels of prohepcidin in patients with PTL need to be more fully investigated.
dc.identifier.doi10.3906/sag-1304-94
dc.identifier.endpage1113
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid25552169
dc.identifier.scopus2-s2.0-84908077121
dc.identifier.scopusqualityQ1
dc.identifier.startpage1108
dc.identifier.trdizinid213234
dc.identifier.urihttps://doi.org/10.3906/sag-1304-94
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/213234
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3862
dc.identifier.volume44
dc.identifier.wosWOS:000344155900029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectSpontaneous preterm labor; term pregnancy; prohepcidin
dc.titleProhepcidin in maternal circulation: is it related to spontaneous preterm labor?
dc.typeArticle

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