Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorNacar, Ahmet
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorKaplan Sefil, Nebihat
dc.contributor.authorNacar, Emel
dc.contributor.authorMotor, Sedat
dc.contributor.authorAkkucuk, Seckin
dc.date.accessioned2025-10-24T18:09:53Z
dc.date.available2025-10-24T18:09:53Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg(-1) day(-1) i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg(-1) day(-1) orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections were stained with hematoxylin and eosin, periodic acid-Schiff, and elastic fiber stain methods. One hundred lobules of liver were examined for each group and evaluated statistically. The levels of malondialdehyde and glutathione peroxidase, as well as the activities of superoxide dismutase, were determined. Results: The cyclosporine group showed significant histopathological changes compared to the control. In the cyclosporine + erdosteine group, histopathological changes of hepatic damage were markedly reduced. Histological findings were supported by biochemical results. Conclusion: Erdosteine could attenuate cyclosporine-induced liver injury.
dc.identifier.doi10.3906/sag-1404-6
dc.identifier.endpage1395
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid26775399
dc.identifier.scopus2-s2.0-84947434789
dc.identifier.scopusqualityQ1
dc.identifier.startpage1390
dc.identifier.trdizinid186574
dc.identifier.urihttps://doi.org/10.3906/sag-1404-6
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/186574
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3875
dc.identifier.volume45
dc.identifier.wosWOS:000365510300031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectCyclosporine; erdosteine; antioxidant system; hepatotoxicity
dc.titleInvestigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods
dc.typeArticle

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