Effects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response

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dc.authoridkavak akelma, fatma/0000-0003-3647-7516|Akinci, Melih/0000-0001-8719-6584;
dc.contributor.authorErgil, Julide
dc.contributor.authorKavak Akelma, Fatma
dc.contributor.authorOzkan, Derya
dc.contributor.authorBumin Aydin, Gozde
dc.contributor.authorGurel, Ayse
dc.contributor.authorAkinci, Melih
dc.date.accessioned2025-10-24T18:09:52Z
dc.date.available2025-10-24T18:09:52Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response. Materials and methods: We enrolled a total of 81 patients in the study. Patients were randomly assigned to receive either 10 mL of 0.9% NaCl (Group P), esmolol 1 mg/kg (Group E), or lidocaine 1.0 mg/kg (Group L). A subparalyzing dose of rocuronium 0.05 mg/kg was administered to all patients and its effects were recorded. Anesthesia was induced with intravenous propofol and intravenous rocuronium 0.5 mg/kg in all groups. The withdrawal movements of the patient groups were subsequently graded. Results: There was a statistically significant difference in overall incidence of pain in group E and L compared to the placebo group after administrating the subparalyzed dose (no pain response: Group E = 81.5%, Group L = 77.8%, Group P = 14.8%) (P < 0.001). After intravenous administration of an intubating dose of rocuronium, the esmolol group had a significantly lower incidence of withdrawal movement than the other groups (no response: Group E = 81.5%, Group L = 63%, Group P = 22.2%) (P < 0.001). Conclusion: We found that esmolol significantly attenuates rocuronium-induced withdrawal movement and also reduces pain when used at subparalyzing doses.
dc.identifier.doi10.3906/sag-1311-79
dc.identifier.endpage963
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid26422874
dc.identifier.scopus2-s2.0-84933048337
dc.identifier.scopusqualityQ1
dc.identifier.startpage959
dc.identifier.trdizinid180840
dc.identifier.urihttps://doi.org/10.3906/sag-1311-79
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/180840
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3870
dc.identifier.volume45
dc.identifier.wosWOS:000359064200035
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectEsmolol; rocuronium; lidocaine; withdrawal movement; injection pain
dc.titleEffects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response
dc.typeArticle

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