Serum Levels of Visfatin and Possible Interaction with Iron Parameters in Gestational Diabetes Mellitus

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dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X;
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorGumus, Ilknur Inegol
dc.contributor.authorYilmaz, Saynur
dc.contributor.authorSimavli, Serap
dc.contributor.authorUysal, Sema
dc.contributor.authorDerbent, Aysel Uysal
dc.contributor.authorGozdemir, Elif
dc.date.accessioned2025-10-24T18:09:28Z
dc.date.available2025-10-24T18:09:28Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/Aims: Visfatin is a novel adipokine with insulinomimetic properties that increases in diabetes. However, for gestational diabetes mellitus (GDM) there are conflicting reports. Recent studies have reported a positive association of serum ferritin concentrations with insulin resistance. Thus, we assessed serum levels of visfatin in pregnant women with varying degrees of glucose tolerance and investigated the possible interaction of visfatin with parameters of iron metabolism. Methods: Visfatin levels were measured at 24-28 weeks of gestation in 88 women who were divided into three groups according to their response to a 50-gram glucose challenge test and a 100-gram oral glucose tolerance test: control group (n = 28), impaired glucose tolerance (IGT) group (n = 30) and GDM group (n = 30). Results: Visfatin levels were significantly higher in the GDM and IGT group than in control (p < 0.001 for GDM vs. control, and p = 0.004 for IGT vs. control). Serum visfatin was significantly associated with serum ferritin, insulin, age, gravidity, and body mass index. In a linear regression model, the covariates explained only 17% of variability of serum visfatin concentration. Body mass index (p < 0.001) contributed independently to visfatin variance. Conclusion: Serum visfatin concentration is significantly higher in GDM and is correlated with ferritin levels. Copyright (C) 2013 S. Karger AG, Basel
dc.description.sponsorshipScientific Research Fund of Fatih University [P53011006_2 (1378)]
dc.description.sponsorshipThis study was approved by Fatih University Ethical Committee and complied with the Helsinki Declaration, including current revisions and the Good Clinical Practice guidelines. All women signed written informed consent before the start of the study. This work is supported by the Scientific Research Fund of Fatih University under project No. P53011006_2 (1378).
dc.identifier.doi10.1159/000348560
dc.identifier.endpage209
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue3
dc.identifier.pmid23548246
dc.identifier.scopus2-s2.0-84876784398
dc.identifier.scopusqualityQ2
dc.identifier.startpage203
dc.identifier.urihttps://doi.org/10.1159/000348560
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3663
dc.identifier.volume75
dc.identifier.wosWOS:000317880400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofGynecologic And Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectVisfatin; Insulin resistance; Ferritin; Gestational diabetes mellitus
dc.titleSerum Levels of Visfatin and Possible Interaction with Iron Parameters in Gestational Diabetes Mellitus
dc.title.alternativeSerum levels of visfatin and possible interaction with iron parameters in gestational diabetes mellitus
dc.typeArticle

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