Serum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome

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dc.contributor.authorKahveci, Hasan
dc.contributor.authorTayman, Cuneyt
dc.contributor.authorLaoglu, Fuat
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorKavas, Nazan
dc.contributor.authorKilic, Omer
dc.contributor.authorAydemir, Salih
dc.date.accessioned2025-10-24T18:08:52Z
dc.date.available2025-10-24T18:08:52Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractInfants with respiratory distress syndrome (RDS) may suffer from severe hypoxia, asphyxia. In this study, we aimed to evaluate serum ischemia-modified albumin (IMA) level as a diagnostic marker for hypoxia in preterm infants with RDS. Thirty-seven premature newborns with RDS were allocated as the study group and 42 healthy preterm neonates were selected as the control group. IMA was measured as absorbance unit (ABSU) in human serum with colorimetric assay method which is based on reduction in albumin cobalt binding. IMA levels were significantly higher in neonates with RDS as compared to the control group (P < 0.001). Cut-off value of IMA (ABSU) was 0.72, the sensitivity level was 91.9 %, the specificity was 78.6 %, positive predictive value was 79.1 % and negative predictive value was 91.7 % at RDS. Area under curve values was 0.93 (P < 0.001; 95 % CI, 0.88-0.98) in the receiver operating characteristic curve. We concluded that elevated blood IMA levels might be accepted as a useful marker for hypoxia in newborn with RDS.
dc.identifier.doi10.1007/s12291-015-0494-0
dc.identifier.endpage42
dc.identifier.issn0970-1915
dc.identifier.issn0974-0422
dc.identifier.issue1
dc.identifier.pmid26855486
dc.identifier.scopus2-s2.0-84956667469
dc.identifier.scopusqualityQ3
dc.identifier.startpage38
dc.identifier.urihttps://doi.org/10.1007/s12291-015-0494-0
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3354
dc.identifier.volume31
dc.identifier.wosWOS:000377530800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal Of Clinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectPrematurity; Newborn; Respiratory distress syndrome; Ischemia modified albumin
dc.titleSerum Ischemia-Modified Albumin in Preterm Babies with Respiratory Distress Syndrome
dc.typeArticle

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