The effect of positive end-expiratory pressure on inflammatory cytokines during laparoscopic cholecystectomy

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dc.contributor.authorYilmazlar, Firdevs
dc.contributor.authorKarabayirli, Safinaz
dc.contributor.authorGzdemir, Muhammet
dc.contributor.authorUsta, Burhanettin
dc.contributor.authorPeker, Murat
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorErdamar, Huesamettin
dc.date.accessioned2025-10-24T18:10:28Z
dc.date.available2025-10-24T18:10:28Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: To investigate effects of the positive end-expiratory pressure (PEEP) application of 10 cm H2O on the plasma levels of cytokines during laparoscopic cholecystectomy. Methods: A prospective study was conducted on 40 patients who presented to the Department of General Surgery, Medical Faculty, Turgut Ozal University, Ankara, Turkey scheduled for laparoscopic cholecystectomy operation during a 10 month period from September 2012 to June 2013. Forty patients scheduled for laparoscopic cholecystectomy operation were randomly divided into 2 groups; ventilation through zero end-expiratory pressure (ZEEP) (0 cm H2O PEEP) (n = 20), and PEEP (10 cm H2O PEEP) (n = 20). All patients were ventilated with 8 ml/kg TV. Levels of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, IL 10, and transforming growth factor (TGF)-beta 1 were measured in the pre- and post-operatively collected samples. Results: Blood samples of 30 patients' were analyzed for plasma cytokine levels, and 10 were excluded from the study due to hemolysis. Post-operative plasma IL-6 levels were observed to be significantly higher than the pre-operative patients (p = 0.035). Post-operative plasma TGF-beta 1 levels in the PEEP group was found significantly higher compared with the pre-operative group levels (p = 0.033). However, there were no significant differences in the pre- and post-operative plasma cytokine levels between the 2 groups. Conclusion: The application of PEEP of 10 cm H2O, which has known beneficial effect on respiratory mechanics, does not have any effect on systemic inflammatory response undergoing pneumoperitoneum during laparoscopic cholecystectomy surgery.
dc.identifier.endpage1362
dc.identifier.issn0379-5284
dc.identifier.issue11
dc.identifier.pmid26593173
dc.identifier.scopus2-s2.0-84949771983
dc.identifier.scopusqualityQ2
dc.identifier.startpage1358
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4181
dc.identifier.volume36
dc.identifier.wosWOS:000366142100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med J
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMechanical Ventilation; Lung; Strategies; Responses
dc.titleThe effect of positive end-expiratory pressure on inflammatory cytokines during laparoscopic cholecystectomy
dc.typeEditorial

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