Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury

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dc.authoridBal, Ceylan/0000-0002-1678-1281;
dc.contributor.authorBal, Ceylan
dc.contributor.authorGungor, Oya Torun
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorAbusoglu, Sedat
dc.contributor.authorUguz, Nihal
dc.contributor.authorTutkun, Engin
dc.contributor.authorYilmaz, Omer Hinc
dc.date.accessioned2025-10-24T18:09:36Z
dc.date.available2025-10-24T18:09:36Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared. Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels. Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant difference between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups. Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.
dc.identifier.doi10.1515/tjb-2015-0011
dc.identifier.endpage264
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84931044702
dc.identifier.scopusqualityQ3
dc.identifier.startpage258
dc.identifier.trdizinid196471
dc.identifier.urihttps://doi.org/10.1515/tjb-2015-0011
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/196471
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3735
dc.identifier.volume40
dc.identifier.wosWOS:000358306700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMercury; cystatin C; creatinine; acute renal damage; glomerular filtration rate
dc.titleAssessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury
dc.title.alternativeAkut civa maruziyeti olan çocuklarda renal fonksiyonların farklı glomerüler fitrasyon hızı formülleriyle değerlendirilmesi
dc.typeArticle

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