Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

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dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorUgurcu, Veli
dc.contributor.authorAltuntas, Aynur
dc.contributor.authorHasgul, Rukiye
dc.contributor.authorCakmak, Ozlem
dc.contributor.authorAkyol, Omer
dc.date.accessioned2025-10-24T18:09:26Z
dc.date.available2025-10-24T18:09:26Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCaffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, antiproliferative, cytotoxic, antiviral, antifungal, and antineoplastic properties. One of the most studied organs for the effects of CAPE is the kidney, particularly in the capacity of this ester to decrease the nephrotoxicity induced by several drugs and the oxidative injury after ischemia/reperfusion (I/R). In this review, we summarized and critically evaluated the current knowledge regarding the protective effect of CAPE in nephrotoxicity induced by several special medicines such as cisplatin, doxorubicin, cyclosporine, gentamycin, methotrexate, and other causes leading to oxidative renal injury, namely, I/R models and senility.
dc.identifier.doi10.1155/2014/561971
dc.identifier.issn1537-744X
dc.identifier.pmid25003138
dc.identifier.scopus2-s2.0-84903648273
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2014/561971
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3649
dc.identifier.wosWOS:000337415400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofScientific World Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectIschemia-Reperfusion Injury; Acute-Renal-Failure; Vancomycin-Induced Nephrotoxicity; Gentamicin-Induced Nephrotoxicity; Nitric-Oxide; Rat Kidneys; In-Vivo; Electromagnetic-Radiation; Preferential Cytotoxicity; Myocardial-Ischemia
dc.titleCaffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review
dc.typeReview Article

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