The relationship between 25-hydroxyvitamin D levels and ambulatory arterial stiffness index in newly diagnosed and never-treated hypertensive patients

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dc.authoridBilgic, Mukadder Ayse/0000-0003-0621-8273|Bozduman Habip, Fadime/0000-0002-9895-1132|ALTINSOY, Meltem/0000-0002-3494-5999
dc.contributor.authorMalcok Gurel, Ozgul
dc.contributor.authorBilgic, Ayse
dc.contributor.authorDemircelik, Bora
dc.contributor.authorOzaydin, Meltem
dc.contributor.authorBozduman, Fadime
dc.contributor.authorAyturk, Zubeyde
dc.contributor.authorYilmaz, Hakki
dc.date.accessioned2025-10-24T18:09:21Z
dc.date.available2025-10-24T18:09:21Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectivesVitamin D insufficiency has been shown to be associated with cardiac dysfunctions, such as cardiac hypertrophy and hypertension, in animal studies. Arterial stiffness is a prognostic marker for cardiovascular disease. Previous studies have demonstrated that 25-hydroxyvitamin D [25(OH)D] levels were negatively correlated with arterial stiffness index. The aim of this study was to investigate the relationship between 25(OH)D levels and arterial stiffness, which is evaluated using an ambulatory arterial stiffness index (AASI), in patients who have untreated and newly diagnosed essential hypertension.DesignA total of 123 consecutive patients with newly diagnosed and untreated essential hypertension were included. Patients were divided into two groups according to their 25(OH)D levels. Vitamin D insufficiency was defined by 25(OH)D levels less than 20ng/ml. All patients were referred for ambulatory blood pressure monitoring. The regression slope of diastolic and systolic blood pressure was computed for each individual on the basis of ambulatory blood pressure readings. AASI was described as one minus the respective regression slope.ResultsThe mean AASI was significantly higher in patients with 25(OH)D levels less than 20 as compared with patients with 25(OH)D levels greater than or equal to 20 (0.500.20 vs. 0.34 +/- 0.17, P<0.001). In Pearson's correlation analysis, AASI had a significantly strong negative correlation with vitamin D levels (r=-0.385, P<0.001). In multivariate linear regression analysis, vitamin D levels were found to be significantly and independently associated with AASI (=-0.317, P=0.035).ConclusionArterial stiffness measured by AASI in newly diagnosed and untreated patients with essential hypertension were significantly related to vitamin D levels.
dc.identifier.doi10.1097/MBP.0000000000000157
dc.identifier.endpage53
dc.identifier.issn1359-5237
dc.identifier.issn1473-5725
dc.identifier.issue1
dc.identifier.pmid26461882
dc.identifier.scopus2-s2.0-84953636573
dc.identifier.scopusqualityQ2
dc.identifier.startpage49
dc.identifier.urihttps://doi.org/10.1097/MBP.0000000000000157
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3576
dc.identifier.volume21
dc.identifier.wosWOS:000373952900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofBlood Pressure Monitoring
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectambulatory arterial stiffness index; arterial stiffness; vitamin D
dc.titleThe relationship between 25-hydroxyvitamin D levels and ambulatory arterial stiffness index in newly diagnosed and never-treated hypertensive patients
dc.typeArticle

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