Power Analysis of C-TDT for Small Sample Size Genome-Wide Association Studies by the Joint Use of Case-Parent Trios and Pairs

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dc.authoridILK, Ozlem/0000-0002-4179-0534;
dc.contributor.authorRajabli, Farid
dc.contributor.authorInan, Gul
dc.contributor.authorIlk, Ozlem
dc.date.accessioned2025-10-24T18:09:25Z
dc.date.available2025-10-24T18:09:25Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn family-based genetic association studies, it is possible to encounter missing genotype information for one of the parents. This leads to a study consisting of both case-parent trios and case-parent pairs. One of the approaches to this problem is permutation-based combined transmission disequilibrium test statistic. However, it is still unknown how powerful this test statistic is with small sample sizes. In this paper, a simulation study is carried out to estimate the power and false positive rate of this test across different sample sizes for a family-based genome-wide association study. It is observed that a statistical power of over 80% and a reasonable false positive rate estimate can be achieved even with a combination of 50 trios and 30 pairs when 2% of the SNPs are assumed to be associated. Moreover, even smaller samples provide high power when smaller percentages of SNPs are associated with the disease.
dc.identifier.doi10.1155/2013/235825
dc.identifier.issn1748-670X
dc.identifier.issn1748-6718
dc.identifier.pmid23737858
dc.identifier.scopus2-s2.0-84877973271
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1155/2013/235825
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3644
dc.identifier.volume2013
dc.identifier.wosWOS:000318936700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofComputational And Mathematical Methods In Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectTransmission Disequilibrium Test; Gene; Permutation
dc.titlePower Analysis of C-TDT for Small Sample Size Genome-Wide Association Studies by the Joint Use of Case-Parent Trios and Pairs
dc.typeArticle

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