Low vitamin D levels are associated with increased risk for fatty liver disease among non-obese adults

Basit Öğe Kaydı
dc.authoridYALCIN, Kadir Serkan/0000-0002-8028-1070;
dc.contributor.authorKasapoglu, B.
dc.contributor.authorTurkay, C.
dc.contributor.authorYalcin, K. S.
dc.contributor.authorCarlioglu, A.
dc.contributor.authorSozen, M.
dc.contributor.authorKoktener, A.
dc.date.accessioned2025-10-24T18:10:14Z
dc.date.available2025-10-24T18:10:14Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractRecent data have revealed an inverse relationship between insulin resistance, which is associated with fatty liver disease, and blood 25-hydroxy-vitamin D (25(OH)D) levels. The aim of the present study was to determine the association of vitamin D levels with the presence and stage of fatty liver disease among non-obese subjects and to determine the effect of vitamin D status on fatty liver disease development. A total of 613 non-obese (body mass index <30 kg/m(2)) gastroenterology and internal medicine outpatients (472 women and 141 men) were enrolled in the study. The patients' laboratory values, including liver function tests, lipid profiles, C-reactive protein, fasting blood glucose, insulin, calcium and 25(OH)D levels were studied. Low vitamin D levels, higher triglyceride levels and higher alanine aminotransferase levels were found to be the significant determinants for non-alcoholic fatty liver disease. When the patients were evaluated as low or normal vitamin D groups, low vitamin D levels was determined to be a risk factor for fatty liver disease, with an odds ratio of -1.59 (confidence interval -1.22 to -1.97). The increased risk for fatty liver disease among patients with low vitamin D status may be suggestive of mechanisms promoting fat flow and accumulation in the liver. Molecular studies are warranted to elucidate the action of vitamin D on the liver with respect to fat metabolism.
dc.identifier.doi10.7861/clinmedicine.13-6-576
dc.identifier.endpage579
dc.identifier.issn1470-2118
dc.identifier.issn1473-4893
dc.identifier.issue6
dc.identifier.pmid24298105
dc.identifier.scopus2-s2.0-84890938597
dc.identifier.scopusqualityQ1
dc.identifier.startpage576
dc.identifier.urihttps://doi.org/10.7861/clinmedicine.13-6-576
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4058
dc.identifier.volume13
dc.identifier.wosWOS:000327926000014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherRoy Coll Phys London Editorial Office
dc.relation.ispartofClinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectFatty liver disease; vitamin D
dc.titleLow vitamin D levels are associated with increased risk for fatty liver disease among non-obese adults
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu