Early Induction of ADAMTS1,-4,-5 and-9 in IL-Stimulated Mouse Astrocytes

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dc.authoridYONEZAWA, Tomoko/0000-0002-3380-8298;
dc.contributor.authorAbali, Osman
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorCemil, Berker
dc.contributor.authorErdogan, Bulent
dc.contributor.authorYonezawa, Tomoko
dc.contributor.authorDemircan, Kadir
dc.date.accessioned2025-10-24T18:10:03Z
dc.date.available2025-10-24T18:10:03Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAIM: Astrocytes and extracellular matrix molecules have important roles in regulating synaptic functions between neurons in the central nervous system. However, under pathological conditions, these constituents are activated to form glial scar that is thought to be harmful for neuronal regeneration. The aim of this study was to evaluate the expression pattern of ADAMTS1, -4, -5 and -9 in IL-1 stimulated astrocyte cultures obtained from postnatal day zero mouse brains. MATERIAL and METHODS: Real time PCR analyses were performed. RESULTS: An overexpression of ADAMTS1, -4, -5 and -9 at the 3-h time point after IL-1 stimulation was found. IL-1 stimulation induced aggrecaneses and this effect was time dependent. Maximum increase was detected at 3-h (six fold increase). Interestingly the expression of ADAMTS1 and -4 appeared to be at the highest expression level but the ADAMTS5 and ADAMTS9 expression level was much weaker (three times and two times respectively). CONCLUSION:To the best of our knowledge, this is the first report demonstrating induction of ADAMTS in IL-1 induced astrocytes. Aggrecanases may play a role in tissue destruction in the progression of central nervous system (CNS) injury and they are differentially expressed in mouse CNS, suggesting a critical role in the pathogenesis of CNS injury. This can be a very crucial aetiologic factor for some neuropsychiatric disorders.
dc.identifier.doi10.5137/1019-5149.JTN.9043-13.2
dc.identifier.endpage524
dc.identifier.issn1019-5149
dc.identifier.issue4
dc.identifier.pmid25050676
dc.identifier.scopus2-s2.0-84905002927
dc.identifier.scopusqualityQ3
dc.identifier.startpage519
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.9043-13.2
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3962
dc.identifier.volume24
dc.identifier.wosWOS:000340227300013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAstrocyte; Extracellular matrix proteins; ADAMTS; Neuronal regeneration
dc.titleEarly Induction of ADAMTS1,-4,-5 and-9 in IL-Stimulated Mouse Astrocytes
dc.title.alternativeEarly induction of ADAMTS1, -4, -5 and -9 in IL-stimulated mouse astrocytes
dc.typeArticle

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