Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns

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dc.authorid0000-0002-4668-9603en_US
dc.contributor.authorDemircan, Mehmet
dc.contributor.authorGürünlüoğlu, Kubilay
dc.contributor.authorGözükara Bağ, Harika Gözde
dc.contributor.authorKoçbıyık, Alper
dc.contributor.authorGül, Mehmet
dc.contributor.authorÜremiş, Nuray
dc.contributor.authorGül, Semir
dc.contributor.authorTürköz, Yusuf
dc.contributor.authorTaşcı, Aytaç
dc.contributor.authorGürünlüoğlu, Semra
dc.date.accessioned2022-03-10T13:27:28Z
dc.date.available2022-03-10T13:27:28Z
dc.date.issued11.12.2020en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-? (TNF-?), Transforming growth factor-?3 (TGF-?3 ) in blood and burnt tissue in children with second-degree burns. METHODS: Children between the ages of one to 16 years, with 25–50% second-degree partial-thickness burns of the total body surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples were taken from the two burn and control groups. IL-6, TNF-?, and TGF-? ?3 levels were evaluated in blood and tissue samples from all groups, and the results were analyzed statistically. RESULTS: In the PLM group, IL-6 and TNF-? levels decreased early days in both serum and tissue samples to reach normal ranges compared with the HFAg group. In the PLM group, TGF-?3 levels were elevated than in other groups for two weeks. CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that PLM increased the level of TGF-?3 , which may be associated with the prevention of the development of hypertrophic scar in the burn wound, in the blood and burn tissue during this studyen_US
dc.identifier.citationDemircan, M., Gürünlüoğlu, K., Gözükara Bağ, H. G., Koçbıyık, A., Gül, M., Üremiş, N., ... & Taşçı, A. (2021). Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns. Turkish Journal of Trauma and Emergency Surgery, 27(1), 122-131.en_US
dc.identifier.doi10.14744/tjtes.2020.30483
dc.identifier.endpage131en_US
dc.identifier.issue1en_US
dc.identifier.pmid33394485
dc.identifier.scopus2-s2.0-85099428890en_US
dc.identifier.startpage122en_US
dc.identifier.uriDOI: 10.14744/tjtes.2020.30483
dc.identifier.urihttps://hdl.handle.net/20.500.12899/595
dc.identifier.volume27en_US
dc.identifier.wosWOS:000604992400021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGürünlüoğlu, Semra
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Trauma and Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBurnsen_US
dc.subjectchildrenen_US
dc.subjectdressingen_US
dc.subjectIL-6en_US
dc.subjecthydrofiber with silveren_US
dc.subjectpolylactic membraneen_US
dc.subjectTNF-α TGF-ben_US
dc.titleImpaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burnsen_US
dc.typeArticleen_US

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