Chemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: A comparative study

Yükleniyor...
Küçük Resim

Tarih

2021

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Institute for Medical Research and Occupational Health

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

The aim of this study was to compare the biological activities of ethanolic propolis extracts of Apis mellifera caucasica obtained from Ardahan and Erzurum provinces of Turkey. Samples were tested for antioxidant, anticytotoxic, anticarcinogenic, antibacterial, and antifungal potentials using different techniques. Propolis samples from the two provinces had different mineral and organic compositions related to their geographical origin. The ferric reducing antioxidant power (FRAP) test showed superiority of Ardahan propolis over the Erzurum. Regardless of origin and the presence of mitomycin C in the culture medium, propolis enhanced human peripheral lymphocyte viability, which depended on the duration and propolis concentration. Antiperoxidative activity on MCF-7 breast cancer cells was concentration-dependent. Erzurum propolis showed the highest anticarcinogenic activity at the concentrations of 62.5 ?g/mL and 125 ?g/ mL, which dropped at higher concentrations. All propolis samples also showed antibacterial activity against the tested human pathogens similar to ampicillin and penicillin controls, except for Pseudomonas aeruginosa. However, they did not exert any antifungal activity against Candida albicans and Yarrowia lipolytica. In conclusion, propolis samples from both provinces showed promising biological activities, but further research should focus on finding the right concentrations for optimal effect and include the cell necrosis pathway to get a better idea of the anticarcinogenic effects.

Açıklama

Anahtar Kelimeler

Anticarcinogen, Antimicrobial, Biological activity, Mineral, Mitomycin C, Organic composition

Kaynak

Arhiv za Higijenu Rada i Toksikologiju

WoS Q Değeri

Scopus Q Değeri

Q3

Cilt

72

Sayı

1

Künye

Arslan, M., Sevgiler, Y., Güven, C., Murathan, Z. T., Erbil, N., Yıldırım, D., ... & Rencüzoğulları, E. (2021). Chemical and biological characteristics of propolis from Apis mellifera caucasica from the Ardahan and Erzurum provinces of Turkey: a comparative study. Arhiv za higijenu rada i toksikologiju, 72(1), 53-69.