Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis

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dc.authoridBilgic, Mukadder Ayse/0000-0003-0621-8273;
dc.contributor.authorYilmaz, H.
dc.contributor.authorCelik, H. T.
dc.contributor.authorGurel, O. M.
dc.contributor.authorBilgic, M. A.
dc.contributor.authorNamuslu, M.
dc.contributor.authorBozkurt, H.
dc.contributor.authorAyyildiz, A.
dc.date.accessioned2025-10-24T18:08:47Z
dc.date.available2025-10-24T18:08:47Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aims. Increased carotid intima-media thickness (CIMT) was shown to be an independent predictor of cardiovascular (CV) mortality in dialysis patients and the general population. Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor superfamily, is produced by cardiomyocytes and atherosclerotic lesions under stress conditions such as inflammation. We assessed associations between serum concentrations of GDF-15, mortality, and CIMT for subclinical atherosclerosis in hemodialysis (HD) patients. Methods. A total of 87 patients on maintenance hemodialysis and 45 sex-and age-matched healthy controls were included in this prospective study. Serum GDF-15 levels were measured by ELISA. CIMT was assessed by Doppler ultrasonography. The association between serum GDF-15 levels and mortality was assessed using Cox regression analysis with serum levels categorized into two groups according to the median value (328.18 pg/ml). Patients were followed for 2 years and cause-specific and all-cause mortality were determined. Results. The median level of serum GDF-15 was significantly higher in HD patients than controls [ 328 (198-522) vs. 176 (101-289) pg/ml, p<0.01, respectively]. Serum GDF-15 levels were correlated to CIMT (r=0.607, p<0.001), C-reactive protein (CRP; r=0.250, p=0.010), HD duration (r=0.376, p=0.004), and serum albumin (r=-0.156, p=0.030). The multivariate analysis revealed that GDF-15 was found to be an independent variable of CIMT in HD patients. In the study, the serum GDF-15 level was an independent marker of all-cause of mortality when adjusted for age, CRP, and history of diabetes mellitus. Conclusion. The relationship between serum GDF-15, mortality, and carotid artery thickening suggests that GDF-15 may be a novel marker of atherosclerosis, inflammation, and malnutrition in HD patients.
dc.identifier.doi10.1007/s00059-014-4139-5
dc.identifier.endpage310
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.pmid25117302
dc.identifier.scopus2-s2.0-84956953842
dc.identifier.scopusqualityQ3
dc.identifier.startpage305
dc.identifier.urihttps://doi.org/10.1007/s00059-014-4139-5
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3296
dc.identifier.volume40
dc.identifier.wosWOS:000362565500015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.ispartofHerz
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGrowth differentiation factor 15; Atherosclerosis; Renal dialysis; Mortality; End-stage kidney disease
dc.titleIncreased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis
dc.typeArticle

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