Loss of heterozygosity in ING3 and ING5 genes in breast cancer

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dc.authoridacar, muradiye/0000-0003-4357-5229|Bayrak, Reyhan/0000-0001-7450-9828|UCTEPE, EYYUP/0000-0002-1820-9094;
dc.contributor.authorGunduz, Esra
dc.contributor.authorNas, Gokhan
dc.contributor.authorAcar, Muradiye
dc.contributor.authorUctepe, Eyyup
dc.contributor.authorBozer, Mikdat
dc.contributor.authorOznur, Murat
dc.contributor.authorBayrak, Reyhan
dc.date.accessioned2025-10-24T18:09:47Z
dc.date.available2025-10-24T18:09:47Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe tumor suppressor genes (TSGs) ING3 and ING5, members of the inhibitor of growth gene family, are effective in inhibition of cell growth and induction of apoptosis. However, in many cancer types, one of the alleles of a TSG is lost through carcinogenesis, while the remaining allele is usually inactivated through a process called loss of heterozygosity (LOH). Previous studies in head and neck cancer revealed that allelic loss and reduced expression is a common pattern of ING gene family members. Fifty paraffin-embedded breast cancer tissues were analyzed by polymerase chain reaction and denatured-polyacrylamide gel electrophoresis for LOH status. The allelic deletion frequency of ING3 and ING5 were detected as 14% and 17% in breast cancer patients, respectively. No significant relationship was detected between ING3 LOH status and clinicopathological variables. Our data also suggest that both ING3 and ING5 LOH statuses have no significant effect in overall survival and disease-free survival of breast cancer patients. These results provide a rational explanation and relative contribution for the complexity of tumor formation, whereby allelic loss of ING3 and ING5 genes is not a major factor for breast cancer but is rather a part of a larger complex mechanism.
dc.description.sponsorshipTurgut Ozal University; Fatih University [P53010913_2]
dc.description.sponsorshipThis work was supported by the Scientific Research Fund of Turgut Ozal University and Fatih University under the project number P53010913_2.
dc.identifier.doi10.3906/biy-1405-73
dc.identifier.endpage905
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84911446211
dc.identifier.scopusqualityQ1
dc.identifier.startpage898
dc.identifier.trdizinid163192
dc.identifier.urihttps://doi.org/10.3906/biy-1405-73
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/163192
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3835
dc.identifier.volume38
dc.identifier.wosWOS:000345431100019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectClinicopathological factors; early diagnosis; survival analysis; tumor suppressor genes
dc.titleLoss of heterozygosity in ING3 and ING5 genes in breast cancer
dc.typeArticle

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