Relationship between late arteriovenous fistula (AVF) stenosis and neutrophil-lymphocyte ratio (NLR) in chronic hemodialysis patients

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dc.authoridBilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorBozkurt, Alper
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorBilgic, Mukadder Ayse
dc.contributor.authorBavbek, Nuket
dc.contributor.authorAkcay, Ali
dc.date.accessioned2025-10-24T18:09:44Z
dc.date.available2025-10-24T18:09:44Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Primary cause of late arteriovenous fistula (AVF) dysfunction is venous stenosis as result of neointimal hyperplasia. The mechanism of AVF stenosis is not exactly understood. But inflammation is a contributing factor for development of AVF stenosis. Neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, and it was investigated in many diseases. The aim of this study was to investigate the relationship between NLR and AVF stenosis in chronic hemodialysis patients. Materials and methods: Of 593 patients applied to the department of interventional radiology between January 2011 and November 2012, a total of 108 patients meeting the appropriate criteria were included in this study. All patients were assessed with Color Doppler ultrasonography and then digital subtraction angiography was used for the patients with abnormal results. Sixty-four patients were classified as patients with AVF stenosis (group 1) and 44 patients without AVF stenosis (group 2). Routine biochemical and complete blood count values measured six months ago were recorded for all patients. Results: Mean NLR (3.47 +/- 0.46 vs. 2.27 +/- 0.22; p < 0.001) was higher in group 1 compared to group 2, whereas high-density lipoprotein (HDL; 31.8 +/- 12.6 mg/dL vs. 51.5 +/- 11.9 mg/dL; p < 0.001) was lower in group 1. NLR level was correlated with degree of AVF stenosis (r = 0.625; p < 0.01). Receiver operating characteristic curve analysis showed that NLR (optimal-cut-off = 2.70) was a useful parameter in prediction of AVF stenosis (AUC = 0.893, sensitivity = 98.4% and specificity = 75%; p < 0.001). NLR level and HDL530 mg/dL in logistic regression analysis are independent predictors of AVF stenosis. Conclusions: For hemodialysis patients with increased level of NLR and decreased level of HDL, regular monitoring with regard to the development of AVF stenosis may be beneficial. Our study suggests that the mechanism of AVF stenosis might have similarities to that of atherosclerosis.
dc.identifier.doi10.3109/0886022X.2014.945183
dc.identifier.endpage1394
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue9
dc.identifier.pmid25246339
dc.identifier.scopus2-s2.0-84907429743
dc.identifier.scopusqualityQ2
dc.identifier.startpage1390
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.945183
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3787
dc.identifier.volume36
dc.identifier.wosWOS:000344391200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAVF stenosis; Color Doppler ultrasonography; digital subtraction angiography; inflammation; NLR
dc.titleRelationship between late arteriovenous fistula (AVF) stenosis and neutrophil-lymphocyte ratio (NLR) in chronic hemodialysis patients
dc.typeArticle

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