Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow

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dc.authoridOzkan, Selcuk/0000-0003-3613-736X|, Mustafa Cetin/0000-0001-7542-6602;
dc.contributor.authorCetin, Mustafa
dc.contributor.authorKiziltunc, Emrullah
dc.contributor.authorElalmis, Ozgul Ucar
dc.contributor.authorCetin, Zehra Guven
dc.contributor.authorDemircelik, Muhammed Bora
dc.contributor.authorCicekcioglu, Hulya
dc.contributor.authorKurtul, Alparslan
dc.date.accessioned2025-10-24T18:10:13Z
dc.date.available2025-10-24T18:10:13Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Increased microvascular resistance due to chronic inflammation is assumed to be one of the mechanisms associated with coronary slow flow (CSF). Previous studies have shown that the platelet-to-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are markers of inflammation for various diseases. In this study we aimed to evaluate the relationship between CSF and PLR-NLR. Methods: Seventy-eight patients with CSF and 50 patients with normal coronary flow were enrolled into this study. The study subjects underwent medical examination and testing, after which their platelet-to-lymphocyte ratios and NLR values were calculated. An independent observer measured the coronary flow rate by Thrombolysis in Myocardial Infarction Frame Count (TFC) method. The platelet-to-lymphocyte ratio and NLR values were compared between the groups and correlation analysis was performed to explore the relationship between mean TFC with PLR and NLR. Results: Platelet-to-lymphocyte ratio and NLR values were significantly higher in patients with CSF (p < 0.001). There was a positive significant correlation between TFC with NLR and PLR (Spearman's Rho: 0.59, p < 0.001 and Spearman's Rho: 0.30, p = 0.001, respectively). Multivariate logistic regression analysis revealed that NLR is the one independent predictor for CSF. Conclusions: This study demonstrated an association between CSF and PLR-NLR. Although the exact mechanism could not be explained, our findings support the possible role of inflammation in CSF physiopathology.
dc.identifier.doi10.6515/ACS20150119I
dc.identifier.endpage312
dc.identifier.issn1011-6842
dc.identifier.issue3
dc.identifier.pmid27274171
dc.identifier.scopus2-s2.0-84969884451
dc.identifier.scopusqualityQ3
dc.identifier.startpage307
dc.identifier.urihttps://doi.org/10.6515/ACS20150119I
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4052
dc.identifier.volume32
dc.identifier.wosWOS:000376219500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaiwan Soc Cardiology
dc.relation.ispartofActa Cardiologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCoronary slow flow; Inflammation; Neutrophil lymphocyte ratio; Platelet lymphocyte ratio
dc.titlePredictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow
dc.typeArticle

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