Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia

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dc.authoridTokmak, Aytekin/0000-0001-5739-5689|SARIKAYA, ESMA/0000-0002-8522-7364|Erkaya, Salim/0000-0003-0331-952X;
dc.contributor.authorGokdemir, Irem Eda
dc.contributor.authorOzdegirmenci, Ozlem
dc.contributor.authorElmas, Burak
dc.contributor.authorSarikaya, Esma
dc.contributor.authorTokmak, Aytekin
dc.contributor.authorKazanci, Fatmanur H.
dc.contributor.authorGok, Sumeyye
dc.date.accessioned2025-10-24T18:09:45Z
dc.date.available2025-10-24T18:09:45Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.Methods: Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.Results: Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p<0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p>0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27ng/ml while the cut-off value for IL-33 was 0.23pg/ml with 82.93% sensitivity and 53.66% specificity.Conclusion: Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.
dc.identifier.doi10.3109/14767058.2015.1087497
dc.identifier.endpage2455
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue15
dc.identifier.pmid26382559
dc.identifier.scopus2-s2.0-84941777564
dc.identifier.scopusqualityQ1
dc.identifier.startpage2450
dc.identifier.urihttps://doi.org/10.3109/14767058.2015.1087497
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3806
dc.identifier.volume29
dc.identifier.wosWOS:000374775200011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectADAMTS12; ADAMTS16; ADAMTS18; IL-33; pre-eclampsia
dc.titleEvaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia
dc.typeArticle

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