IMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMETRIAL LEUKOCYTES IN IMPLANTATION PERIOD IN RATS WITH STREPTOZOTOSIN-INDUCED DIABETES

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dc.contributor.authorNacar, Emel
dc.contributor.authorBozkurt, Yesim Akaydin
dc.contributor.authorKoc, Ahmet
dc.contributor.authorNacar, Ahmet
dc.date.accessioned2025-10-24T18:10:03Z
dc.date.available2025-10-24T18:10:03Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOur first aim was to determine the total leukocyte profile in implantation. Second aim was to detect the changes in uterine leukocyte profile in diabetes, a common accompanying disease. For this purpose 4 groups are formed with Wistar albino rats weighing 250-300 g. Two of the groups were non-diabetic and two of them were diabetic. One of the diabetic and one of the non-diabetic groups were left pregnant. Then uterus tissues of pregnant animals were removed in the 5th and 7th days of pregnancy together with tissues of other two non-pregnant groups. Tissues were analyzed immunohistochemically with antibodies CD45, CD3, CD4, CD8, CD56, CD68 and CD79a. It was revealed that pregnancy increased immune staining of CD68, CD3, CD45 and CD56 in endometrium. In addition it was observed that immune staining density of CD68, CD45 and CD56 decreased in diabetes. In the histopathological examination, significant degeneration was detected in the endometrium of diabetic rats. Diabetes could decrease leukocyte proportions in decidua in early pregnancy periods. Therefore immune cell therapies could be administrated in diabetes related problems of pregnancy.
dc.description.sponsorshipMustafa Kemal University Scientific Projects Unit [1004 D 0105]
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Scientific Projects Unit with Project Number 1004 D 0105.
dc.identifier.doi10.5114/PJP.2016.59191
dc.identifier.endpage59
dc.identifier.issn1233-9687
dc.identifier.issue1
dc.identifier.pmid27179275
dc.identifier.scopus2-s2.0-84966687266
dc.identifier.scopusqualityQ4
dc.identifier.startpage54
dc.identifier.urihttps://doi.org/10.5114/PJP.2016.59191
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3959
dc.identifier.volume67
dc.identifier.wosWOS:000375804800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVesalius Univ Medical Publ
dc.relation.ispartofPolish Journal Of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectimplantation; diabetes; endometrium; immunohistochemistry; rat; immune cells
dc.titleIMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMETRIAL LEUKOCYTES IN IMPLANTATION PERIOD IN RATS WITH STREPTOZOTOSIN-INDUCED DIABETES
dc.title.alternativeImmunohistochemical investigation of endometrial leukocytes in implantation period in rats with streptozotosin-induced diabetes
dc.typeArticle

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