The role of reactive oxygen species and oxidative stress in carbon monoxide toxicity: An in-depth analysis

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dc.authoridDANE, SENOL/0000-0001-5572-9454;
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorErdogan, Serpil
dc.contributor.authorIdiz, Nuri
dc.contributor.authorCelik, Safa
dc.contributor.authorKaya, Mehmet
dc.contributor.authorUcar, Fatma
dc.contributor.authorDane, Senol
dc.date.accessioned2025-10-24T18:09:33Z
dc.date.available2025-10-24T18:09:33Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe underlying mechanism of the central nervous system (CNS) injury after acute carbon monoxide (CO) poisoning is interlaced with multiple factors including apoptosis, abnormal inflammatory responses, hypoxia, and ischemia/reperfusion-like problems. One of the current hypotheses with regard to the molecular mechanism of CO poisoning is the oxidative injury induced by reactive oxygen species, free radicals, and neuronal nitric oxide. Up to now, the relevant mechanism of this injury remains poorly understood. The weakening of antioxidant systems and the increase of lipid peroxidation in the CNS have been implicated, however. Accordingly, in this review, we will highlight the relationship between oxidative stress and CO poisoning from the perspective of forensic toxicology and molecular toxicology.
dc.identifier.doi10.1179/1351000214Y.0000000094
dc.identifier.endpage189
dc.identifier.issn1351-0002
dc.identifier.issue5
dc.identifier.pmid24773392
dc.identifier.scopus2-s2.0-84903792761
dc.identifier.scopusqualityQ2
dc.identifier.startpage180
dc.identifier.urihttps://doi.org/10.1179/1351000214Y.0000000094
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3691
dc.identifier.volume19
dc.identifier.wosWOS:000339668500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherManey Publishing
dc.relation.ispartofRedox Report
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectToxicity; Carbon monoxide; Reactive oxygen species; Free radicals; Oxidative damage
dc.titleThe role of reactive oxygen species and oxidative stress in carbon monoxide toxicity: An in-depth analysis
dc.typeReview Article

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