Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

Basit Öğe Kaydı
dc.authoridDuzgun, Ulkuhan/0000-0001-9759-6960|KOC, EMINE RABIA/0000-0002-0264-7284;
dc.contributor.authorErsoy, Alevtina
dc.contributor.authorKoc, Emine Rabia
dc.contributor.authorSahin, Semsettin
dc.contributor.authorDuzgun, Ulkuhan
dc.contributor.authorAcar, Burcu
dc.contributor.authorIlhan, Atilla
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe problem of noise has recently gained more attention as it has become an integral part of our daily lives. However, its influence has yet to be fully elucidated. Other than being an unpleasant stimulus, noise may cause health disorders through annoyance and stress, including oxidative stress. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, may possess antioxidant properties. Based on rat models, our project investigates the effect of rosuvastatin on noise-induced oxidative stress in the brain tissue. Thirty-two male Wistar albino rats were used. The rats were divided into four groups: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage, and control. After the data had been collected, oxidant and antioxidant parameters were analyzed in the cerebral cortex, brain stem, and cerebellum. Results indicated that superoxide dismutase values were significantly decreased in the cerebral cortex, while malondialdehyde values in the brainstem and cerebellum were significantly increased in the group with only noise exposure. Superoxide dismutase values in the brainstem were significantly increased, but nitric oxide values in the cerebellum and brainstem and malondialdehyde values in the cerebellum and cerebral cortex were significantly decreased in the group where only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased superoxide dismutase values in the cerebral cortex and brainstem, but significantly reduced malondialdehyde values in the brain stem. Consequently, our data show that brain tissue was affected by oxidative stress due to continued exposure to noise. This noise-induced stress decreases with rosuvastatin therapy.
dc.description.sponsorshipScientific Research Fund of Fatih University
dc.description.sponsorshipSource of Support: This work supported by Scientific Research Fund of Fatih University, Conflict of Interest: None declared.
dc.identifier.doi10.4103/1463-1741.127849
dc.identifier.endpage25
dc.identifier.issn1463-1741
dc.identifier.issn1998-4030
dc.identifier.issue68
dc.identifier.pmid24583676
dc.identifier.scopus2-s2.0-84897786773
dc.identifier.scopusqualityQ3
dc.identifier.startpage18
dc.identifier.urihttps://doi.org/10.4103/1463-1741.127849
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3894
dc.identifier.volume16
dc.identifier.wosWOS:000332521600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofNoise & Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectBrain; noise; oxidant/antioxidant parameters; oxidative stress; rosuvastatin
dc.titlePossible effects of rosuvastatin on noise-induced oxidative stress in rat brain
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu