Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma

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dc.contributor.authorKilic, Murat Ozgur
dc.contributor.authorAynekin, Busra
dc.contributor.authorBozer, Mikdat
dc.contributor.authorKara, Adem
dc.contributor.authorHaltas, Hacer
dc.contributor.authorIcen, Duygu
dc.contributor.authorDemircan, Kadir
dc.date.accessioned2025-10-24T18:10:02Z
dc.date.available2025-10-24T18:10:02Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction: Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various biological processes such as ECM remodelling and anti-angiogenesis. Aim: To investigate the expression of ADAMTS1, 8, 9, and 18 proteinases in pancreas adenocarcinoma and its nodal metastasis. Material and methods: The immunostaining status of ADAMTS1, 8, 9, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent pancreaticoduodenectomy for an adenocarcinoma located at the head of the pancreas. Results: In semi-quantitive grading pathologically, ADAMTS1, 8, 9, and 18 were found to be highly stained in all cancerous pancreas samples compared with normal pancreas. In addition, the immune positivity of ADAMTS1, 9, and 18 was found to be higher in metastatic lymph nodes than in non-metastatic lymph tissue. Tumour size was correlated with ADAMTS9 and 18 expressions in cancerous pancreas. Conclusions: According to the data obtained from the study, we suggest that these four ADAMTSs may have significant roles in the tumorigenesis and nodal spread of pancreas adenocarcinoma.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) (3001 Project) [114S233]; Foundation of Scientific Research of Turgut Ozal University, Ankara, Turkey [005-10-2013]
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (3001 Project no: 114S233) and the Foundation of Scientific Research of Turgut Ozal University, Ankara, Turkey (No: 005-10-2013).
dc.identifier.doi10.5114/pg.2017.72101
dc.identifier.endpage270
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue4
dc.identifier.pmid29358995
dc.identifier.scopus2-s2.0-85038956855
dc.identifier.scopusqualityQ3
dc.identifier.startpage262
dc.identifier.urihttps://doi.org/10.5114/pg.2017.72101
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3958
dc.identifier.volume12
dc.identifier.wosWOS:000419457500005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofGastroenterology Review-Przeglad Gastroenterologiczny
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectADAMTS; immunohistochemistry; pancreas cancer
dc.titleDifferentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma
dc.typeArticle

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