Melatonin protects kidney against apoptosis induced by acute unilateral ureteral obstruction in rats

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dc.authoridBayrak, Reyhan/0000-0001-7450-9828|YILDIRIM, MEHMET/0000-0003-4768-4537;
dc.contributor.authorYildirim, Mehmet Erol
dc.contributor.authorBadem, Huseyin
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorKosem, Bahadir
dc.contributor.authorKaratas, Omer Faruk
dc.contributor.authorBayrak, Reyhan
dc.date.accessioned2025-10-24T18:10:08Z
dc.date.available2025-10-24T18:10:08Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction To investigate whether there was a protective effect of melatonin on apoptotic mechanisms after an acute unilateral obstruction of the kidney. Material and methods A total of 25 rats consisting of five groups were used in the study, designated as follows: Group 1: control, Group 2: sham, Group 3: unilateral ureteral obstruction treated with only saline, Group 4: unilateral ureteral obstruction treated with melatonin immediately, and Group 5: unilateral obstruction treated with melatonin one day after obstruction. Melatonin was administered as a 10 mg/kg dose intraperitoneally. The kidneys were evaluated according to the apoptotic index and Ki-67 scores. Results Comparison of all obstruction groups (Group 3, 4, and 5), revealed that the apoptotic index was significantly higher in Groups 1 and 2. Despite melatonin reduced apoptotic mechanisms in Groups 4 and 5, there was no significant difference between Groups 4 and 5 in terms of the reduction of apoptosis. However, the reduction of apoptosis in the melatonin treated group did not decrease to the level of Groups 1 and 2. Conclusions Despite melatonin administration, which significantly reduces the apoptotic index occurring after acute unilateral ureteral obstruction, the present study did not observe a return to normal renal histology in the obstruction groups.
dc.identifier.doi10.5173/ceju.2016.770
dc.identifier.endpage230
dc.identifier.issn2080-4806
dc.identifier.issn2080-4873
dc.identifier.issue2
dc.identifier.pmid27551563
dc.identifier.scopus2-s2.0-84975159422
dc.identifier.scopusqualityQ3
dc.identifier.startpage225
dc.identifier.urihttps://doi.org/10.5173/ceju.2016.770
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3994
dc.identifier.volume69
dc.identifier.wosWOS:000378596400017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPolish Urological Assoc
dc.relation.ispartofCentral European Journal Of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectmelatonin; kidney; obstruction; apoptosis; hypoxia; antioxidant
dc.titleMelatonin protects kidney against apoptosis induced by acute unilateral ureteral obstruction in rats
dc.typeArticle

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