Can Serum Gdf-15 be Associated with Functional Iron Deficiency in Hemodialysis Patients?

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dc.authoridBilgic, Mukadder Ayse/0000-0003-0621-8273|Darcin, Tahir/0000-0001-5073-1790;
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorDarcin, Tahir
dc.contributor.authorInan, Osman
dc.contributor.authorBilgic, Mukadder Ayse
dc.contributor.authorBavbek, Nuket
dc.contributor.authorAkcay, Ali
dc.date.accessioned2025-10-24T18:08:52Z
dc.date.available2025-10-24T18:08:52Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractFunctional iron deficiency (FID) incidence is gradually increasing in hemodialysis (HD) patients. Recently, high levels of GDF-15 supressed the iron regulatory protein hepcidin and GDF-15 expression increased in iron-deficient patients. The relationship between FID, GDF-15, and hepcidin is currently unknown. The present study aimed to evaluate the association between GDF-15, hepcidin, and FID in chronic HD patients. Serum GDF-15 and hepcidin concentrations were measured in 105 HD patients and 40 controls. FID is defined as serum ferritin > 800 ng/mL, TSAT < 25 %, Hb levels < 11 g/dL, and reticulocyte haemoglobin content (CHr) < 29 pg. Serum GDF-15 and hepcidin levels were increased significantly in HD patients with FID, compared to HD patients without anemia and controls. GDF-15 correlated with ferritin, hepcidin, and CRP in the entire cohort. GDF-15 was related to ferritin and CRP in HD patients with FID. GDF-15 is better diagnostic marker than hepcidin for detection of FID [AUC = 0.982 (0.013) versus AUC = 0.921 (0.027); P = 0.0324]. GDF-15 appears to be a promising tool for detection of FID. High levels of ferritin and CRP correlated with GDF-15. Our results support GDF-15 as a new mediator of FID via hepcidin, chronic inflammation, or unknown pathways.
dc.identifier.doi10.1007/s12288-015-0551-0
dc.identifier.endpage227
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue2
dc.identifier.pmid27065587
dc.identifier.scopus2-s2.0-84961169968
dc.identifier.scopusqualityQ3
dc.identifier.startpage221
dc.identifier.urihttps://doi.org/10.1007/s12288-015-0551-0
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3352
dc.identifier.volume32
dc.identifier.wosWOS:000372248600017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal Of Hematology And Blood Transfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAnemia; GDF-15; Iron; Inflammation
dc.titleCan Serum Gdf-15 be Associated with Functional Iron Deficiency in Hemodialysis Patients?
dc.typeArticle

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