Protective Effect of Selenium Against Cisplatin-Induced Ototoxicity in an Experimental Design

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dc.authoridAlicura Tokgoz, Sibel/0000-0002-5058-1400
dc.contributor.authorDogan, Sedat
dc.contributor.authorYazici, Hasmet
dc.contributor.authorYalcinkaya, Esin
dc.contributor.authorErdogdu, Halil Ibrahim
dc.contributor.authorTokgoz, Sibel Alicura
dc.contributor.authorSarici, Furkan
dc.contributor.authorNamuslu, Mehmet
dc.date.accessioned2025-10-24T18:09:21Z
dc.date.available2025-10-24T18:09:21Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCisplatin is an effective chemotherapeutic agent in the treatment of several types of malignant solid tumors but its clinical use is associated with ototoxicity. In the present study, we investigated the effect of selenium administration on lipid peroxidation (malondialdehyde [MDA]) and cisplatin-induced ototoxicity in rats. Healthy wistar albino rats (n=21) were randomly divided into 3 groups: control (C), cisplatin (Cis), cisplatin and selenium (Cis+Se). Cisplatin was administered for 3 days to Cis and Cis+Se groups. Cis+Se group received selenium 5 days before cisplatin injection and continued for 11 consecutive days. Hearing thresholds and lipid peroxidation (MDA) levels of the rats were recorded before injections and at the end of experimental protocol. The cochleas of animals were harvested for histologic and immunuhistochemical examinations. In biochemichal analyses, pretreatment with selenium prevented the elevation of MDA levels in Cis+Se group rats. Moreover, animals in Cis+Se group had better hearing threshold levels than animals in cis group. Samples obtained from the animals in Cis group revealed extensive loss of the normal microarchitecture of the organ of Corti. On the other hand, animals in Cis+Se group exhibited a preservation of the morphology of the organ of Corti and outer hair cells. In the immunohistochemical examinations of cochlear tissues stained with anti-caspase-3, a higher degree of immunopositivity was found in the Cis group. When Cis+Se group and Cis group were compared, significantly less immunopositivity occurred in the Cis+Se group (P<0.05). Thus, it appears that pretreatment with selenium may reduce cisplatin-induced ototoxicity in rats.
dc.identifier.doi10.1097/SCS.0000000000002942
dc.identifier.endpageE614
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue7
dc.identifier.pmid27741210
dc.identifier.scopus2-s2.0-85040682692
dc.identifier.scopusqualityQ3
dc.identifier.startpageE610
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002942
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3584
dc.identifier.volume27
dc.identifier.wosWOS:000386352100011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCisplatin; hearing loss; ototoxicity; selenium
dc.titleProtective Effect of Selenium Against Cisplatin-Induced Ototoxicity in an Experimental Design
dc.title.alternativeProtective effect of selenium against cisplatin-induced ototoxicity in an experimental design
dc.typeArticle

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