Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
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Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Behçet disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 genes mediate the activation and migration of neutrophils. Aim: To investigate CXCR1, CXCR2 and CXCL5 single nucleotide polymorphisms (SNPs) and examine their association with BD. Methods: We studied polymorphic sites in CXCR1 (four sites: rs16858811, rs9282752, rs16858809 and rs16858808), CXCR2 (three sites: rs2230054, rs1126579 and rs1126580) and CXCL5 (one site: rs352046) in 87 patients with BD and 111 healthy controls (HCs), using a PCR restriction-fragment length polymorphism-based approach for genotyping. Results: We found that the CXCR2 rs2230054 TT genotype and the CXCL5 rs352046 polymorphism might be possible genetic factors responsible for BD. We did not find any association between the development of BD and any of the four CXCR1 polymorphisms or the other two CXCR2 SNPs. In addition, our haplotype analysis results indicated that the haplotypes of the CXCR2 and CXCR1–CXCR2 polymorphic loci were different between the BD and HC groups. Conclusion: Our study suggests that polymorphisms of CXCR1, CXCR2 and CXCL5 may affect susceptibility to BD and increase the risk of developing the disease. These loci need to be studied in larger groups of patients from different geographical areas around the world in order to clarify the genetic background for BD pathogenesis. © 2021 British Association of Dermatologists
Açıklama
Anahtar Kelimeler
Polymorphisms in Behcet disease
Kaynak
Clinical and Experimental Dermatology
WoS Q Değeri
Q1
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Künye
Arıkan, S., Atalay, A., Öztürk, O., Duygulu, Ş., & Atalay, E. Ö. (2021). Association of Single Nucleotide Polymorphisms in the CXCR1, CXCR2 and CXCL5 with the Behçet's Disease in Denizli Province of Turkey. Clinical and Experimental Dermatology.
