Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate

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dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorIsik, Bunyamin
dc.contributor.authorAltuntas, Aynur
dc.contributor.authorErden, Gonul
dc.contributor.authorCakmak, Ozlem
dc.contributor.authorKursunlu, Fatih
dc.contributor.authorAdam, Bahattin
dc.date.accessioned2025-10-24T18:09:47Z
dc.date.available2025-10-24T18:09:47Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCaffeic acid phenethyl ester (CAPE) is an important active component of propolis, which is derived from honeybee hives. It has received increasing attention in a variety of medical and pharmaceutical research, due to its anti-oxidant, antiproliferative, anti-inflammatory, antiviral and antifungal activity, in addition to its antineoplastic properties. Besides the use of CAPE as an antioxidant and anti-inflammatory agent in a number of in vivo studies of ear disease, its beneficial effects have been reported in the treatment of cancer, arthritis, allergies, heart disease, diabetes, kidney disease, liver disease and neurological disease. CAPE influences a number of biochemical pathways, as well as several targets involved in ear diseases, in particular, in ototoxicity. The protective effects of CAPE in ototoxicity, which may be induced by a number factors, including lipopolysaccharides, hydrogen peroxide and streptomycin, are evaluated and discussed in the present review.
dc.identifier.doi10.3892/mmr.2015.3785
dc.identifier.endpage3235
dc.identifier.issn1791-2997
dc.identifier.issn1791-3004
dc.identifier.issue3
dc.identifier.pmid25975288
dc.identifier.scopus2-s2.0-84935480925
dc.identifier.scopusqualityQ1
dc.identifier.startpage3231
dc.identifier.urihttps://doi.org/10.3892/mmr.2015.3785
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3832
dc.identifier.volume12
dc.identifier.wosWOS:000359933900002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofMolecular Medicine Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectcaffeic acid phenethyl ester; ear; ototoxicity; protection; antioxidant
dc.titleFuture opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate
dc.title.alternativeFuture opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (review)
dc.typeReview Article

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